Endogenous opiate peptides in the spinal cord are involved in the analgesia of hypothalamic paraventricular nucleus in the rat

被引：14

作者：

Yang, Jun ^{[1
]}

Yang, Yu ^{[1
]}

Chu, Jiegen ^{[1
]}

Wang, Gen ^{[2
]}

Xu, Hongtao ^{[3
]}

Liu, Wen-Yan ^{[4
]}

Wang, Cheng-Hai ^{[5
]}

Lin, Bao-Cheng ^{[5
]}

机构：

[1] Jiangsu Taizhou Res Inst Novel Pharmaceut, Yangtze River Pharmaceut Grp, Taizhou 225321, Jiangsu, Peoples R China

[2] Natl Res Council Canada, Inst Nutrisci & Hlth, Charlottetown, PE C1A 5T1, Canada

[3] McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada

[4] Jining Med Coll, Dept Physiol, Jining 272113, Shangdong, Peoples R China

[5] Second Mil Med Univ, Dept Neurobiol, Shanghai 200433, Peoples R China

来源：

PEPTIDES | 2009年 / 30卷 / 04期

基金：

美国国家科学基金会;

关键词：

Hypothalamic paraventricular nucleus; Analgesia; Endogenous opiate peptide; Arginine vasopressin; Spinal cord; ARGININE-VASOPRESSIN; ACUPUNCTURE ANALGESIA; PERIAQUEDUCTAL GRAY; SUPRAOPTIC NUCLEUS; OXYTOCIN; ANTINOCICEPTION; PAIN; NOCICEPTION; ENKEPHALIN; NEURONS;

D O I：

10.1016/j.peptides.2009.01.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Many studies have shown that hypothalamic paraventricular nucleus (PVN) plays a role in pain process, and endogenous opiate peptide system in the spinal cord is involved in nociception. This communication was designed to study the relationship between PVN and endogenous opiate system in the spinal cord in the rat. The results showed that in both the thoracic and the lumber spinal cord, microinjection of 100 ng L-glutamate sodium into PVN could increase leucine-enkephalin (L-Ek), beta-endorphin (beta-Ep), dynorphinA(1-13) (DynA(1-13)) concentrations and PVN cauterization decreased L-Ek and beta-Ep concentrations. Pretreatment of the spinal cord with 5 mu g naloxone, an opiate receptor antagonist could partly reverse the analgesia induced by microinjection of 100 ng L-glutamate sodium into PVN. The data suggested that PVN analgesia might be involved in the endogenous opiate peptide system in the spinal cord independently. (c) 2009 Elsevier Inc. All rights reserved.

引用

页码：740 / 744

页数：5

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