Getting to the guts of HIV pathogenesis

被引：80

作者：

Veazey, RS ^{[1
]}

Lackner, AA ^{[1
]}

机构：

[1] Tulane Univ, Sch Med, Tulane Natl Primate Res Ctr, Covington, LA 70433 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2004年 / 200卷 / 06期

关键词：

D O I：

10.1084/jem.20041464

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two groups have shown that, as in macaques infected with simian immunodeficiency virus (SIV), intestinal CD4(+) T cells are selectively and rapidly depleted in the intestine of HIV-infected patients. Depletion of intestinal CD4(+) T cells occurred at all stages of infection regardless of highly active antiretroviral therapy (HAART). Here we discuss the important implications of these papers for our understanding of FRV pathogenesis, treatment, and vaccine design.

引用

页码：697 / 700

页数：4

共 15 条

[1] Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue [J].

Anton, PA ;

Elliott, J ;

Poles, MA ;

McGowan, IM ;

Matud, J ;

Hultin, LE ;

Grovit-Ferbas, K ;

Mackay, CR ;

Chen, ISY ;

Giorgi, JV .

AIDS, 2000, 14 (12) :1761-1765

[2] Multiple measures of HIV burden in blood and tissue are correlated with each other but not with clinical parameters in aviremic subjects [J].

Anton, PA ;

Mitsuyasu, RT ;

Deeks, SG ;

Scadden, DT ;

Wagner, B ;

Huang, C ;

Macken, C ;

Richman, DD ;

Christopherson, C ;

Borellini, F ;

Lazar, R ;

Hege, KM .

AIDS, 2003, 17 (01) :53-63

[3] CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract [J].

Brenchley, JM ;

Schacker, TW ;

Ruff, LE ;

Price, DA ;

Taylor, JH ;

Beilman, GJ ;

Nguyen, PL ;

Khoruts, A ;

Larson, M ;

Haase, AT ;

Douek, DC .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (06) :749-759

[4] RAPID TURNOVER OF PLASMA VIRIONS AND CD4 LYMPHOCYTES IN HIV-1 INFECTION [J].

HO, DD ;

NEUMANN, AU ;

PERELSON, AS ;

CHEN, W ;

LEONARD, JM ;

MARKOWITZ, M .

NATURE, 1995, 373 (6510) :123-126

[5]

LACKNER AA, 1994, AM J PATHOL, V145, P428

[6] Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract [J].

Mehandru, S ;

Poles, MA ;

Tenner-Racz, K ;

Horowitz, A ;

Hurley, A ;

Hogan, C ;

Boden, D ;

Racz, P ;

Markowitz, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (06) :761-770

[7] LOSS OF CD4 T-LYMPHOCYTES IN PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 IS MORE PRONOUNCED IN THE DUODENAL MUCOSA THAN IN THE PERIPHERAL-BLOOD [J].

SCHNEIDER, T ;

JAHN, HU ;

SCHMIDT, W ;

RIECKEN, EO ;

ZEITZ, M ;

ULLRICH, R .

GUT, 1995, 37 (04) :524-529

[8] Trafficking of human immunodeficiency virus type 1-specific CD8+ T cells to gut-associated lymphoid tissue during chronic infection [J].

Shacklett, BL ;

Cox, CA ;

Sandberg, JK ;

Stollman, NH ;

Jacobson, MA ;

Nixon, DF .

JOURNAL OF VIROLOGY, 2003, 77 (10) :5621-5631

[9] Early immunologic events in mucosal and systemic lymphoid tissues after intrarectal inoculation with simian immunodeficiency virus [J].

Vajdy, M ;

Veazey, R ;

Tham, I ;

deBakker, C ;

Westmoreland, S ;

Neutra, M ;

Lackner, A .

JOURNAL OF INFECTIOUS DISEASES, 2001, 184 (08) :1007-1014

[10]

Veazey Ronald, 2003, AIDS Rev, V5, P245

← 1 2 →