Getting to the guts of HIV pathogenesis

被引：80

作者：

Veazey, RS ^{[1
]}

Lackner, AA ^{[1
]}

机构：

[1] Tulane Univ, Sch Med, Tulane Natl Primate Res Ctr, Covington, LA 70433 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2004年 / 200卷 / 06期

关键词：

D O I：

10.1084/jem.20041464

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two groups have shown that, as in macaques infected with simian immunodeficiency virus (SIV), intestinal CD4(+) T cells are selectively and rapidly depleted in the intestine of HIV-infected patients. Depletion of intestinal CD4(+) T cells occurred at all stages of infection regardless of highly active antiretroviral therapy (HAART). Here we discuss the important implications of these papers for our understanding of FRV pathogenesis, treatment, and vaccine design.

引用

页码：697 / 700

页数：4

共 15 条

[11] Identifying the target cell in primary simian immunodeficiency virus (SIV) infection:: Highly activated memory CD4+ T cells are rapidly eliminated in early SIV infection in vivo [J].

Veazey, RS ;

Tham, IC ;

Mansfield, KG ;

DeMaria, M ;

Forand, AE ;

Shvetz, DE ;

Chalifoux, LV ;

Sehgal, PK ;

Lackner, AA .

JOURNAL OF VIROLOGY, 2000, 74 (01) :57-64

[12] Simian immunodeficiency virus infection in neonatal macaques [J].

Veazey, RS ;

Lifson, JD ;

Pandrea, I ;

Purcell, J ;

Piatak, M ;

Lackner, AA .

JOURNAL OF VIROLOGY, 2003, 77 (16) :8783-8792

[13] Vaginal CD4+ T cells express high levels of CCR5 and are rapidly depleted in simian immunodeficiency virus infection [J].

Veazey, RS ;

Marx, PA ;

Lackner, AA .

JOURNAL OF INFECTIOUS DISEASES, 2003, 187 (05) :769-776

[14] The mucosal immune system: primary target for HIV infection and AIDS [J].

Veazey, RS ;

Marx, PA ;

Lackner, AA .

TRENDS IN IMMUNOLOGY, 2001, 22 (11) :626-633

[15] Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection [J].

Veazey, RS ;

DeMaria, M ;

Chalifoux, LV ;

Shvetz, DE ;

Pauley, DR ;

Knight, HL ;

Rosenzweig, M ;

Johnson, RP ;

Desrosiers, RC ;

Lackner, AA .

SCIENCE, 1998, 280 (5362) :427-431

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