Limited diagnostic capacities of two commercial assays for the detection of Leptospira immunoglobulin m antibodies in Laos

被引：51

作者：

Blacksell, Stuart D. ^{[1
]}

Smythe, Lee

Phetsouvanh, Rattanaphone

Dohnt, Michael

Hartskeerl, Rudy

SymondS, Meegan

Slack, Andrew

Vongsouvath, Manivanh

Davong, Viengmone

Lattana, Olay

Phongmany, Simmaly

Keolouangkot, Valy

White, Nicholas J.

Day, Nicholas P. J.

Newton, Paul N.

机构：

[1] Mahosot Hosp, Wellcome Trust Mahosot Hosp Oxford Med Res Collab, Microbiol Lab, Viangchan, Laos

[2] Univ Oxford, Ctr Clin Vaccinol & Trop Med, Churchill Hosp, Oxford OX3 7LJ, England

[3] Mahidol Univ, Fac Trop Med, Bangkok 10400, Thailand

[4] WHO, FAO, OIE, Collaborating Ctr Reference & Res Leptospirosoi, Coopers Plains, Qld 4108, Australia

[5] WHO, FAO, OIE, Collaborating Ctr Reference & Res Leptospirosoi, NL-1105 AZ Amsterdam, Netherlands

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2006年 / 13卷 / 10期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/CVI.00219-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The diagnostic utility of immunochromatographic (Leptotek) and enzyme-linked immunosorbent assay (ELISA; Panbio) tests for the detection of Leptospira immunoglobulin M antibodies was assessed in febrile adults admitted in Vientiane, Laos. Both tests demonstrated poor diagnostic accuracy using admission serum (Leptotek sensitivity of 47.3% and specificity of 75.5%: ELISA sensitivity of 60.9% and specificity of 65.6%) compared to the Leptospira "gold standard" microscopic agglutination test.

引用

页码：1166 / 1169

页数：4

共 11 条

[1] Evaluation of four commercially available rapid serologic tests for diagnosis of leptospirosis [J].