How complete are current yeast and human protein-interaction networks?

被引：278

作者：

Hart, G. Traver ^{[1
]}

Ramani, Arun K. ^{[1
]}

Marcotte, Edward M. ^{[1
]}

机构：

[1] Univ Texas, Inst Mol & Cellular Biol, Ctr Syst & Synth Biol, Austin, TX 78712 USA

来源：

GENOME BIOLOGY | 2006年 / 7卷 / 11期

关键词：

D O I：

10.1186/gb-2006-7-11-120

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We estimate the full yeast protein-protein interaction network to contain 37,800-75,500 interactions and the human network 154,000-369,000, but owing to a high false-positive rate, current maps are roughly only 50% and 10% complete, respectively. Paradoxically, releasing raw, unfiltered assay data might help separate true from false interactions.

引用

页数：9

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