Cobalt-catalyzed intramolecular [2+2+2] cocyclotrimerization of nitrilediynes: An efficient route to tetra- and pentacyclic pyridine derivatives

被引：76

作者：

Chang, Hong-Tai ^{[1
]}

Jeganmohan, Masilamani ^{[1
]}

Cheng, Chien-Hong ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 03期

关键词：

D O I：

10.1021/ol062988t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this paper, we wish to report the intramolecular [2 + 2 + 2] cocyclotrimerization of nitrilediynes catalyzed by the CoI2(dppe)/Zn system at 80 degrees C in CH3CN. Under these reaction conditions, various highly substituted nitrilediynes having steric conjunction at the alpha and beta positions to a nitrile group and a bulkier substitution at the terminal carbon of alkyne undergo [2 + 2 + 2] cocylotrimerization to afford tetra- and pentacyclic pyridine derivatives in good to excellent yields.

引用

页码：505 / 508

页数：4

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