Developmental expression of progesterone receptor isoforms in the mouse midbrain

被引：27

作者：

Beyer, C ^{[1
]}

Damm, N ^{[1
]}

Brito, V ^{[1
]}

Küppers, E ^{[1
]}

机构：

[1] Univ Ulm, D-89061 Ulm, Germany

来源：

NEUROREPORT | 2002年 / 13卷 / 06期

关键词：

development; isoforms; midbrain; progesterone receptor; rt-pcr;

D O I：

10.1097/00001756-200205070-00028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Progesterone participates in the regulation of developmental processes in the brain and controls the function of distinct neural circuits. We have studied the expression of progesterone receptor (PR) isoforms in the developing and adult male and female mouse ventral midbrain. Transcripts of both receptor isoforms (PR-A and B) were detectable pre- and postnatally but regulated differentially during ontogeny Immunoblotting revealed that only the full-length form (PR-B) is transcribed transiently into protein, whereas the truncated PR-A isoform is not detectable as protein. Although the precise function of progesterone in the developing CNS is not fully understood, our data implicate a potential role for PR signaling for the developing nigrostriatal system. NeuroReport 13:877-880 (C) 2002 Lippincott Williams Wilkins.

引用

页码：877 / 880

页数：4

共 28 条

[1]

Beyer C, 2000, J NEUROSCI RES, V59, P107, DOI 10.1002/(SICI)1097-4547(20000101)59:1<107::AID-JNR13>3.3.CO

[2]

2-N

[3] Estrogen and the developing mammalian brain [J].