Crystallization at the polymer/calclum-phosphate interface in a sterilized injectable bone substitute IBS

被引:25
作者
Schmitt, M
Weiss, P
Bourges, X
del Valle, GA
Daculsi, G
机构
[1] Fac Dent, UFR Odontol, Res Ctr Mat Biol Interest, INSERM, F-44042 Nantes 01, France
[2] Biomatlante ZA, F-44360 Vigneux de Bretagne, France
关键词
calcium phosphate ceramic; biomaterial; interface; cellulose ether;
D O I
10.1016/S0142-9612(02)00015-7
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Calcium phosphate (CaP) ceramics are the main raw, materials used to elaborate blocks or granules for bone substitutes. In this study injectable bone Substitutes (1BS) were developed for application,, it) orthopedic or dental surgery. Sterile, ready-to-use composite containing CaP granules (biphasic calcium phosphate. BCP) and polymer (hydroxypropylmethylcellulose, HPMC) was prepared. Steam sterilization produced ne. phenomena at the CaP polymer interface. resulting in crystal growth. These phenomena may constitute a model for the biomineralization study. Scanning electron microscopy showed that the formed crystallites organize themselves into a three-dimensional structure. Currently, the mechanisms of crystal growth are unknown and have been observed with only one combination of polymer BCP ceramics after steam sterilization. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2789 / 2794
页数:6
相关论文
共 28 条
[1]   The effect of fluoride on apatite structure and growth [J].
Aoba, T .
CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE, 1997, 8 (02) :136-153
[2]   Light scattering experiments on aqueous solutions of selected cellulose ethers: contribution to the study of polymer-mineral interactions in a new injectable biomaterial [J].
Bohic, S ;
Weiss, P ;
Roger, P ;
Daculsi, G .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2001, 12 (03) :201-205
[3]  
Bouler JM, 2000, J BIOMED MATER RES, V51, P680, DOI 10.1002/1097-4636(20000915)51:4<680::AID-JBM16>3.0.CO
[4]  
2-#
[5]  
CHRISTIANSEN DL, 1993, CELL MATER, V3, P177
[6]   SKELETAL REPAIR BY IN-SITU FORMATION OF THE MINERAL PHASE OF BONE [J].
CONSTANTZ, BR ;
ISON, IC ;
FULMER, MT ;
POSER, RD ;
SMITH, ST ;
VANWAGONER, M ;
ROSS, J ;
GOLDSTEIN, SA ;
JUPITER, JB ;
ROSENTHAL, DI .
SCIENCE, 1995, 267 (5205) :1796-1799
[7]   FORMATION OF CARBONATE-APATITE CRYSTALS AFTER IMPLANTATION OF CALCIUM-PHOSPHATE CERAMICS [J].
DACULSI, G ;
LEGEROS, RZ ;
HEUGHEBAERT, M ;
BARBIEUX, I .
CALCIFIED TISSUE INTERNATIONAL, 1990, 46 (01) :20-27
[8]   Biphasic calcium phosphate/hydrosoluble polymer composites: A new concept for bone and dental substitution biomaterials [J].
Daculsi, G ;
Weiss, P ;
Bouler, JM ;
Gauthier, O ;
Millot, F ;
Aguado, E .
BONE, 1999, 25 (02) :59S-61S
[9]  
Daculsi G, 1997, INT REV CYTOL, V172, P129, DOI 10.1016/S0074-7696(08)62360-8
[10]   CALCIUM-BINDING TO D-GLUCURONATE RESIDUES - CRYSTAL-STRUCTURE OF A HYDRATED CALCIUM BROMIDE SALT OF D-GLUCURONIC ACID [J].
DELUCAS, L ;
BUGG, CE ;
TERZIS, A ;
RIVEST, R .
CARBOHYDRATE RESEARCH, 1975, 41 (MAY) :19-29