Crystallization at the polymer/calclum-phosphate interface in a sterilized injectable bone substitute IBS

被引：25

作者：

Schmitt, M

Weiss, P

Bourges, X

del Valle, GA

Daculsi, G

机构：

[1] Fac Dent, UFR Odontol, Res Ctr Mat Biol Interest, INSERM, F-44042 Nantes 01, France

[2] Biomatlante ZA, F-44360 Vigneux de Bretagne, France

来源：

BIOMATERIALS | 2002年 / 23卷 / 13期

关键词：

calcium phosphate ceramic; biomaterial; interface; cellulose ether;

D O I：

10.1016/S0142-9612(02)00015-7

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Calcium phosphate (CaP) ceramics are the main raw, materials used to elaborate blocks or granules for bone substitutes. In this study injectable bone Substitutes (1BS) were developed for application,, it) orthopedic or dental surgery. Sterile, ready-to-use composite containing CaP granules (biphasic calcium phosphate. BCP) and polymer (hydroxypropylmethylcellulose, HPMC) was prepared. Steam sterilization produced ne. phenomena at the CaP polymer interface. resulting in crystal growth. These phenomena may constitute a model for the biomineralization study. Scanning electron microscopy showed that the formed crystallites organize themselves into a three-dimensional structure. Currently, the mechanisms of crystal growth are unknown and have been observed with only one combination of polymer BCP ceramics after steam sterilization. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2789 / 2794

页数：6

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