Optical imaging of intrinsic signals: recent developments in the methodology and its applications

被引：86

作者：

Zapeda, A

Arias, C

Sengpiel, F

机构：

[1] Cardiff Univ, Cardiff Sch Biosci, Cardiff CF10 3US, S Glam, Wales

[2] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Biol Celular & Fisiol, Mexico City 04510, DF, Mexico

来源：

JOURNAL OF NEUROSCIENCE METHODS | 2004年 / 136卷 / 01期

基金：

英国医学研究理事会;

关键词：

optical imaging; intrinsic signals; event-related; Fourier analysis; functional architecture; development; plasticity;

D O I：

10.1016/j.jneumeth.2004.02.025

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Since optical imaging (OI) of intrinsic signals was first developed in the 1980s, significant advances have been made regarding our understanding of the origins of the recorded signals. The technique has been refined and the range of its applications has been broadened considerably. Here we review recent developments in methodology and data analysis as well as the latest findings on how intrinsic signals are related to metabolic cost and electrophysiological activity in the brain. We give an overview of what optical imaging has contributed to our knowledge of the functional architecture of sensory cortices, their development and plasticity. Finally, we discuss the utility of OI for functional studies of the human brain as well as in animal models of neuropathology. (C) 2004 Elsevier B.V All rights reserved.

引用

页码：1 / 21

页数：21

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[81] Orientation-specific relationship between populations of excitatory and inhibitory lateral connections in the visual cortex of the cat [J].