Farnesyl protein transferase inhibitors and other therapies targeting the ras signal transduction pathway

被引：91

作者：

End, DW ^{[1
]}

机构：

[1] Janssen Res Fdn, Dept Oncol, Spring House, PA 19477 USA

来源：

INVESTIGATIONAL NEW DRUGS | 1999年 / 17卷 / 03期

关键词：

Ras; Raf kinase; MEK; farnesyl protein transferase (FPT);

D O I：

10.1023/A:1006380320290

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The year 2000 will be a significant date for the field of Ras-related therapies since numerous agents will have Phase II clinical efficacy data maturing to provide proof of principle for this cancer treatment strategy. These data will also provide an important milestone for the cancer research community since these molecules represent a small vanguard of oncology drug discovery projects predicated on molecular targets. We can only hope that these agents are a successful harbinger for the formidable number of targeted therapies that will be entering development pipelines in the coming years.

引用

页码：241 / 258

页数：18

共 134 条

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