The habenular nuclei: a conserved asymmetric relay station in the vertebrate brain

被引：255

作者：

Bianco, Isaac H. ^{[1
,2
]}

Wilson, Stephen W. ^{[2
]}

机构：

[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[2] UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2009年 / 364卷 / 1519期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

habenula; asymmetry; interpeduncular nucleus; zebrafish; dorsal diencephalic conduction system; HYDROXYINDOLE-O-METHYLTRANSFERASE; ELASMOBRANCH SCYLLIUM-STELLARE; DIENCEPHALIC CONDUCTION SYSTEM; CYCLASE-ACTIVATING PEPTIDE; MEDIAL PREFRONTAL CORTEX; NITRIC-OXIDE SYNTHASE; LEFT-RIGHT DIFFERENCE; DORSAL RAPHE NUCLEUS; LATERAL HABENULA; INTERPEDUNCULAR NUCLEUS;

D O I：

10.1098/rstb.2008.0213

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The dorsal diencephalon, or epithalamus, contains the bilaterally paired habenular nuclei and the pineal complex. The habenulae form part of the dorsal diencephalic conduction (DDC) system, a highly conserved pathway found in all vertebrates. In this review, we shall describe the neuroanatomy of the DDC, consider its physiology and behavioural involvement, and discuss examples of neural asymmetries within both habenular circuitry and the pineal complex. We will discuss studies in zebrafish, which have examined the organization and development of this circuit, uncovered how asymmetry is represented at the level of individual neurons and determined how such left-right differences arise during development.

引用

页码：1005 / 1020

页数：16

共 136 条

[71] Habenula lesions alter synaptic plasticity within the fimbria-accumbens pathway in the rat [J].

Lecourtier, L. ;

Deschaux, O. ;

Arnaud, C. ;

Chessel, A. ;

Kelly, P. H. ;

Garcia, R. .

NEUROSCIENCE, 2006, 141 (02) :1025-1032

[72] Bilateral lesions of the habenula induce attentional disturbances in rats [J].

Lecourtier, L ;

Kelly, PH .

NEUROPSYCHOPHARMACOLOGY, 2005, 30 (03) :484-496

[73] Habenula lesions cause impaired cognitive performance in rats: implications for schizophrenia [J].

Lecourtier, L ;

Neijt, HC ;

Kelly, PH .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2004, 19 (09) :2551-2560

[74] Differential tonic influence of lateral habenula on prefrontal cortex and nucleus accumbens dopamine release [J].

Lecourtier, Lucas ;

DeFrancesco, Alicia ;

Moghaddam, Bita .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2008, 27 (07) :1755-1762

[75] A conductor hidden in the orchestra? Role of the habenular complex in monoamine transmission and cognition [J].

Lecourtier, Lucas ;

Kelly, Peter H. .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2007, 31 (05) :658-672

[76] ROLE OF LATERAL HABENULA IN THE REGULATION OF EXPLORATORY-BEHAVIOR AND ITS RELATIONSHIP TO STRESS IN RATS [J].

LEE, EHY ;

HUANG, SL .

BEHAVIOURAL BRAIN RESEARCH, 1988, 30 (03) :265-271

[77] SUBDIVISIONS OF THE INTERPEDUNCULAR NUCLEUS - A PROPOSED NOMENCLATURE [J].

LENN, NJ ;

HAMILL, GS .

BRAIN RESEARCH BULLETIN, 1984, 13 (01) :203-204

[78]

Liang JO, 2000, DEVELOPMENT, V127, P5101

[79] SELECTIVE ACTIVATION OF THE MESOCORTICO-FRONTAL DOPAMINERGIC-NEURONS INDUCED BY LESION OF THE HABENULA IN THE RAT [J].

LISOPRAWSKI, A ;

HERVE, D ;

BLANC, G ;

GLOWINSKI, J ;

TASSIN, JP .

BRAIN RESEARCH, 1980, 183 (01) :229-234

[80] REGIONAL BRAIN GLUCOSE-METABOLISM IS ALTERED DURING RAPID EYE-MOVEMENT SLEEP IN THE CAT - A PRELIMINARY-STUDY [J].

LYDIC, R ;

BAGHDOYAN, HA ;

HIBBARD, L ;

BONYAK, EV ;

DEJOSEPH, MR ;

HAWKINS, RA .

JOURNAL OF COMPARATIVE NEUROLOGY, 1991, 304 (04) :517-529

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