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Sequence sensitivity of breathing dynamics in heteropolymer DNA

被引：64
作者：
Ambjornsson, Tobias
Banik, Suman K.
Krichevsky, Oleg
Metzler, Ralf
机构：
[1] NORDITA, DK-2100 Copenhagen O, Denmark
[2] Virginia Polytech Inst & State Univ, Dept Phys, Blacksburg, VA 24061 USA
[3] Ben Gurion Univ Negev, Dept Phys, IL-84105 Beer Sheva, Israel
来源：
PHYSICAL REVIEW LETTERS | 2006年 / 97卷 / 12期
关键词：
D O I：
10.1103/PhysRevLett.97.128105
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
We study the fluctuation dynamics of localized denaturation bubbles in heteropolymer DNA with a master equation and complementary stochastic simulation based on novel DNA stability data. A significant dependence of opening probability and waiting time between bubble events on the local DNA sequence is revealed and quantified for a biological sequence of the T7 bacteriophage. Quantitative agreement with data from fluorescence correlation spectroscopy is demonstrated.
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页数：4
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