Wnt inhibitory factor-1: a candidate for a new player in tumorigenesis of intestinal epithelial cells

被引：31

作者：

Cebrat, M ^{[1
]}

Strzadala, L ^{[1
]}

Kisielow, P ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Immunol & Expt Therapy, PL-53114 Wroclaw, Poland

来源：

CANCER LETTERS | 2004年 / 206卷 / 01期

关键词：

Wif-1; Apc(Min/+) mice; intestinal adenomas; cDNA-representational difference analysis;

D O I：

10.1016/j.canlet.2003.10.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Using cDNA-Representational Difference Analysis it was found that expression of Opg, Ctse, Krt2-4, Fut-2, 24p3 and Wif-1 genes was elevated in intestinal adenomas as compared to normal epithelial cells of Apc(Min/+) mutant mice. Expression of Wif-1, which encodes Wnt inhibitory factor-1 was also detected in a number of tumor cell lines of epithelial cell origin including two human colon adenocarcinoma cell lines. The possible role of Wif-1 over-expression in the etiology of colorectal cancer is discussed. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：107 / 113

页数：7

共 25 条

[1]

Araki Y, 2003, CANCER RES, V63, P728

[2] Linking colorectal cancer to Wnt signaling [J].

Bienz, M ;

Clevers, H .

CELL, 2000, 103 (02) :311-320

[3] The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors [J].

Crawford, HC ;

Fingleton, BM ;

Rudolph-Owen, LA ;

Goss, KJH ;

Rubinfeld, B ;

Polakis, P ;

Matrisian, LM .

ONCOGENE, 1999, 18 (18) :2883-2891

[4] Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction [J].

Glinka, A ;

Wu, W ;

Delius, H ;

Monaghan, AP ;

Blumenstock, C ;

Niehrs, C .

NATURE, 1998, 391 (6665) :357-362

[5] Identification of c-MYC as a target of the APC pathway [J].

He, TC ;

Sparks, AB ;

Rago, C ;

Hermeking, H ;

Zawel, L ;

da Costa, LT ;

Morin, PJ ;

Vogelstein, B ;

Kinzler, KW .

SCIENCE, 1998, 281 (5382) :1509-1512

[6]

Hlubek F, 2001, CANCER RES, V61, P8089

[7]

Holen I, 2002, CANCER RES, V62, P1619

[8] A new secreted protein that binds to Wnt proteins and inhibits their activities [J].

Hsieh, JC ;

Kodjabachian, L ;

Rebbert, ML ;

Rattner, A ;

Smallwood, PM ;

Samos, CH ;

Nusse, R ;

Dawid, IB ;

Nathans, J .

NATURE, 1999, 398 (6726) :431-436

[9]

Hubank M, 1999, METHOD ENZYMOL, V303, P325

[10] Lessons from hereditary colorectal cancer [J].

Kinzler, KW ;

Vogelstein, B .

CELL, 1996, 87 (02) :159-170

← 1 2 3 →