Total synthesis and structural assignment of spongidepsin through a stereodivergent ring-closing-metathesis strategy

被引：43

作者：

Chen, JH ^{[1
]}

Forsyth, CJ ^{[1
]}

机构：

[1] Univ Minnesota, Inst Technol, Dept Chem, Minneapolis, MN 55455 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 16期

关键词：

cyclization; metathesis; natural products; structure elucidation; total synthesis;

D O I：

10.1002/anie.200453663

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Eight diastereomeric probes (1) were generated to synthesize the novel, anti-proliferative marine natural product spongidepsin (2) and to determine its absolute stereochemistry. A key step was the formation of the macrocycle by ring-closing metathesis.

引用

页码：2148 / 2152

页数：5

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