Desymmetrization of dichloroazaheterocycles

被引：34

作者：

Goodman, AJ

Stanforth, SP ^{[1
]}

Tarbit, B

机构：

[1] Northumbria Univ, Dept Chem & Life Sci, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England

[2] Seal Sands Chem Ltd, Middlesbrough TS2 1UB, Cleveland, England

来源：

TETRAHEDRON | 1999年 / 55卷 / 52期

关键词：

D O I：

10.1016/S0040-4020(99)00961-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3,6-Dichloropyridizine 1a was converted in good;yield into its mono-iodo derivative 1b when treated with a mixture of hydriodic acid and sodium iodide. Pure samples of the mono-iodo derivatives 2b, 3b and 4b could not be obtained from their corresponding dichlorinated precursors with these reagents. Compounds Ib and 4b underwent palladium catalysed Suzuki, Sonogashira and other coupling reactions. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：15067 / 15070

页数：4

共 11 条

[1] IMIDAZO[1,2-B]PYRIDAZINES .1. SOME 3-ALKOXY-6-HALOGENO-2-PHENYL-(AND 4'-SUBSTITUTED PHENYL)IMIDAZO[1,2-B]PYRIDAZINES AND 3-METHOXY-2,6-DIPHENYLIMIDAZO[1,2-B]PYRIDAZINE
BARLIN, GB
[J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1986, 39 (11) : 1803 - 1809
[2] NUCLEOPHILIC SUBSTITUTION AT PYRIDAZINE RING CARBONS .1. SYNTHESIS OF IODOPYRIDAZINES
COAD, P
SALISBURY, R
HYEPOCK, J
WILKINS, C
ADAMSCOA.R
CLOUGH, S
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1963, 28 (01) : 218 - &
[3] SYNTHESIS AND ACTIVITY OF 6-ARYL-3-(HYDROXYPOLYMETHYLENEAMINO)PYRIDAZINES IN ANIMAL-MODELS OF EPILEPSY
HALLOT, A
BRODIN, R
MERLIER, J
BROCHARD, J
CHAMBON, JP
BIZIERE, K
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (03) : 369 - 375
[4] C-13 NUCLEAR-MAGNETIC-RESONANCE SPECTRA OF 3,6-DISUBSTITUTED PYRIDAZINES
HEINISCH, G
HOLZER, W
[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1991, 69 (06): : 972 - 977
[5] MIXED HETEROARENE OLIGOMERS
MINATO, A
SUZUKI, K
TAMAO, K
KUMADA, M
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1984, (08) : 511 - 513
[6] OHSAWA A, 1980, CHEM PHARM BULL, V28, P3488
[7] Synthesis and metalation of trifluoromethylpyrimidines. Metalation of diazines .16.
Ple, N
Turck, A
Heynderickx, A
Queguiner, G
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1997, 34 (02) : 551 - 556
[8] CHLOROSULFONYL ISOCYANATE - AN UNUSUAL CHLORINATING AGENT
SRINIVASAN, TN
RAO, KR
SATTUR, PB
[J]. SYNTHETIC COMMUNICATIONS, 1986, 16 (05) : 543 - 546
[9] Catalytic cross-coupling reactions in biaryl synthesis
Stanforth, SP
[J]. TETRAHEDRON, 1998, 54 (3-4) : 263 - 303
[10] SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITY OF NEW 6-HETEROARYL-3-HYDRAZINOPYRIDAZINE DERIVATIVES
STEINER, G
GRIES, J
LENKE, D
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (01) : 59 - 63

← 1 2 →