Chemical modifications rescue off-target effects of RNAi

被引：31

作者：

Snove, Ola, Jr. ^{[1
]}

Rossi, John J. ^{[1
]}

机构：

[1] Beckman Res Inst, Div Mol Biol, Grad Sch Biol Sci, Duarte, CA 91010 USA

来源：

ACS CHEMICAL BIOLOGY | 2006年 / 1卷 / 05期

关键词：

D O I：

10.1021/cb6002256

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNAi's specificity has been questioned for some time. Three recent papers show that off-target effects should be considered normal, but one paper also provides insight on how chemical modifications of siRNAs may overcome the problem.

引用

页码：274 / 276

页数：3

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