How fungi keep time:: circadian system in Neurospora and other fungi

被引：108

作者：

Dunlap, Jay C. ^{[1
]}

Loros, Jennifer J. ^{[1
]}

机构：

[1] Dartmouth Med Sch, Dept Genet, Hanover, NH 03755 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2006年 / 9卷 / 06期

关键词：

D O I：

10.1016/j.mib.2006.10.008

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The circadian system in Neurospora remains a premier model system for understanding circadian rhythms, and evidence has now begun to accumulate suggesting broad conservation of rhythmicity amongst the filamentous fungi. A well-described transcription-translation-based negative feedback loop involving the FREQUENCY, WHITE COLLAR-1 and WHITE COLLAR-2 proteins is integral to the Neurospora system. Recent advances include descriptions of the surprisingly complex frequency transcription unit, an enhanced appreciation of the roles of kinases and their regulation in the generation of, the circadian rhythm and their links to the cell cycle, and strong evidence for an additional WHITE COLLAR-associated feedback loop. Documentation of sequence homologs of integral circadian and photoresponsive proteins amongst the 42 available sequenced fungal genomes suggests unexpected roles for circadian timing among both pathogens and saprophytes.

引用

页码：579 / 587

页数：9

共 91 条

[31] White collar-1, a circadian blue light photoreceptor, binding to the frequency promoter [J].

Froehlich, AC ;

Liu, Y ;

Loros, JJ ;

Dunlap, JC .

SCIENCE, 2002, 297 (5582) :815-819

[32] Alternative initiation of translation and time-specific phosphorylation yield multiple forms of the essential clock protein FREQUENCY [J].

Garceau, NY ;

Liu, Y ;

Loros, JJ ;

Dunlap, JC .

CELL, 1997, 89 (03) :469-476

[33] Theoretical models for circadian rhythms in Neurospora and Drosophila [J].

Gonze, D ;

Leloup, JC ;

Goldbeter, A .

COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES, 2000, 323 (01) :57-67

[34] Robustness of circadian rhythms with respect to molecular noise [J].

Gonze, D ;

Halloy, J ;

Goldbeter, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) :673-678

[35] A PEST-like element in FREQUENCY determines the length of the circadian period in Neurospora crassa [J].

Görl, M ;

Merrow, M ;

Huttner, B ;

Johnson, J ;

Roenneberg, T ;

Brunner, M .

EMBO JOURNAL, 2001, 20 (24) :7074-7084

[36] A circadian oscillator in Aspergillus spp. regulates daily development and gene expression [J].

Greene, AV ;

Keller, N ;

Haas, H ;

Bell-Pedersen, D .

EUKARYOTIC CELL, 2003, 2 (02) :231-237

[37] The COP9 signalosome regulates the Neurospora circadian clock by controlling the stability of the SCFFWD-1 complex [J].

He, Q ;

Cheng, P ;

He, QY ;

Liu, Y .

GENES & DEVELOPMENT, 2005, 19 (13) :1518-1531

[38] FWD1-mediated degradation of FREQUENCY in Neurospora establishes a conserved mechanism for circadian clock regulation [J].

He, Q ;

Cheng, P ;

Yang, YH ;

He, QY ;

Yu, HT ;

Liu, Y .

EMBO JOURNAL, 2003, 22 (17) :4421-4430

[39] CKI and CKII mediate the FREQUENCY-dependent phosphorylation of the WHITE COLLAR complex to close the Neurospora circadian negative feedback loop [J].

He, Qun ;

Cha, Joonseok ;

He, Qiyang ;

Lee, Heng-Chi ;

Yang, Yuhong ;

Liu, Yi .

GENES & DEVELOPMENT, 2006, 20 (18) :2552-2565

[40] Molecular mechanism of light responses in Neurospora:: from light-induced transcription to photoadaptation [J].

He, QY ;

Liu, Y .

GENES & DEVELOPMENT, 2005, 19 (23) :2888-2899

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