Biological Implications and Regulatory Mechanisms of Long-range Chromosomal Interactions

被引：14

作者：

Wei, Zong ^{[1
,2
]}

Huang, David ^{[1
,2
]}

Gao, Fan ^{[1
,2
,3
]}

Chang, Wen-Hsuan ^{[1
,2
]}

An, Woojin ^{[2
]}

Coetzee, Gerhard A. ^{[4
,5
]}

Wang, Kai ^{[3
]}

Lu, Wange ^{[2
]}

机构：

[1] Univ So Calif, Keck Sch Med, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Los Angeles, CA 90033 USA

[2] Univ So Calif, Keck Sch Med, Dept Biochem & Mol Biol, Los Angeles, CA 90033 USA

[3] Univ So Calif, Keck Sch Med, Zilkha Neurogenet Inst, Dept Prevent Med & Psychiat, Los Angeles, CA 90033 USA

[4] Univ So Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Dept Prevent Med, Los Angeles, CA 90033 USA

[5] Univ So Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Dept Urol, Los Angeles, CA 90033 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2013年 / 288卷 / 31期

关键词：

RNA-POLYMERASE-II; GLOBIN LOCUS REQUIRES; CHROMATIN INTERACTIONS; SPATIAL-ORGANIZATION; NUCLEAR SPECKLES; TRANSCRIPTION; GENOME; TRANSLOCATIONS; DOMAINS; GENES;

D O I：

10.1074/jbc.R113.485292

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Development of high-throughput sequencing-based methods has enabled us to examine nuclear architecture at unprecedented resolution, allowing further examination of the function of long-range chromosomal interactions. Here, we review methods used to investigate novel long-range chromosomal interactions and genome-wide organization of chromatin. We further discuss transcriptional activation and silencing in relation to organization and positioning of gene loci and regulation of chromatin organization through protein complexes and noncoding RNAs.

引用

页码：22369 / 22377

页数：9

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