Delineating the Epithelial Hierarchy in the Mouse Mammary Gland

被引：32

作者：

Asselin-Labat, M. -L. ^{[1
]}

Vaillant, F. ^{[1
]}

Shackleton, M. ^{[1
]}

Bouras, T. ^{[1
]}

Lindeman, G. J. ^{[1
]}

Visvader, J. E. ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, VBCRC Lab, Melbourne, Vic 3050, Australia

来源：

CONTROL AND REGULATION OF STEM CELLS | 2008年 / 73卷

关键词：

D O I：

10.1101/sqb.2008.73.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Reconstitution assays have shown that mouse mammary stem cells reside within the mature mammary gland in vivo. Single Cells Could be prospectively isolated and shown to regenerate an entire mammary gland that exhibited full developmental capacity, The more recent identification of luminal progenitor populations has indicated that the mammary epithelium is organized in a hierarchical manner. Further definition of epithelial cell types in both mouse and human mammary glands will provide insight into the "cells of origin" in the different subtypes of breast cancer, as well as the nature of cancer-propagating cells. Here, we review the known characteristics of mammary stern and progenitor cells, their steroid receptor status, and the pathways that have thus far been implicated in regulating their self-renewal and differentiation.

引用

页码：469 / 478

页数：10

共 94 条

[1] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[2] Phenotypic characterization of murine primitive hematopoietic progenitor cells isolated on basis of aldehyde dehydrogenase activity [J].

Armstrong, L ;

Stojkovic, M ;

Dimmick, I ;

Ahmad, S ;

Stojkovic, P ;

Hole, N ;

Lako, M .

STEM CELLS, 2004, 22 (07) :1142-1151

[3] Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation [J].

Asselin-Labat, Marie-Liesse ;

Sutherland, Kate D. ;

Barker, Holly ;

Thomas, Richard ;

Shackleton, Mark ;

Forrest, Natasha C. ;

Hartley, Lynne ;

Robb, Lorraine ;

Grosveld, Frank G. ;

van der Wees, Jacqueline ;

Lindeman, Geoffrey J. ;

Visvader, Jane E. .

NATURE CELL BIOLOGY, 2007, 9 (02) :201-U103

[4] Steroid hormone receptor status of mouse mammary stem cells [J].

Asselin-Labat, Marie-Liesse ;

Shackleton, Mark ;

Stingl, John ;

Vaillant, Francois ;

Forrest, Natasha C. ;

Eaves, Connie J. ;

Visvader, Jane E. ;

Lindeman, Geoffrey J. .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2006, 98 (14) :1011-1014

[5] Mammary Gland Development and Tumorigenesis in Estrogen Receptor Knockout Mice [J].

Bocchinfuso, Wayne P. ;

Korach, Kenneth S. .

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 1997, 2 (04) :323-334

[6]

Bocchinfuso WP, 1999, CANCER RES, V59, P1869

[7] Fitting limiting dilution experiments with generalized linear models results in a test of the single-hit Poisson assumption [J].

Bonnefoix, T ;

Bonnefoix, P ;

Verdiel, P ;

Sotto, JJ .

JOURNAL OF IMMUNOLOGICAL METHODS, 1996, 194 (02) :113-119

[8] Estrogen receptor-α and progesterone receptor are expressed in label-retaining mammary epithelial cells that divide asymmetrically and retain their template DNA strands [J].

Booth, Brian W. ;

Smith, Gilbert H. .

BREAST CANCER RESEARCH, 2006, 8 (04)

[9] Reducing mammary cancer risk through premature stem cell senescence [J].

Boulanger, CA ;

Smith, GH .

ONCOGENE, 2001, 20 (18) :2264-2272

[10] Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-β1 expression [J].

Boulanger, CA ;

Wagner, KU ;

Smith, GH .

ONCOGENE, 2005, 24 (04) :552-560

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