Delineating the Epithelial Hierarchy in the Mouse Mammary Gland

被引：32

作者：

Asselin-Labat, M. -L. ^{[1
]}

Vaillant, F. ^{[1
]}

Shackleton, M. ^{[1
]}

Bouras, T. ^{[1
]}

Lindeman, G. J. ^{[1
]}

Visvader, J. E. ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, VBCRC Lab, Melbourne, Vic 3050, Australia

来源：

CONTROL AND REGULATION OF STEM CELLS | 2008年 / 73卷

关键词：

D O I：

10.1101/sqb.2008.73.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Reconstitution assays have shown that mouse mammary stem cells reside within the mature mammary gland in vivo. Single Cells Could be prospectively isolated and shown to regenerate an entire mammary gland that exhibited full developmental capacity, The more recent identification of luminal progenitor populations has indicated that the mammary epithelium is organized in a hierarchical manner. Further definition of epithelial cell types in both mouse and human mammary glands will provide insight into the "cells of origin" in the different subtypes of breast cancer, as well as the nature of cancer-propagating cells. Here, we review the known characteristics of mammary stern and progenitor cells, their steroid receptor status, and the pathways that have thus far been implicated in regulating their self-renewal and differentiation.

引用

页码：469 / 478

页数：10

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