Incidence and relevance of secondary chromosome abnormalities in childhood TEL/AML1+ acute lymphoblastic leukemia:: an interphase FISH analysis

被引：64

作者：

Attarbaschi, A ^{[1
]}

Mann, G ^{[1
]}

König, M ^{[1
]}

Dworzak, MN ^{[1
]}

Trebo, MM ^{[1
]}

Mühlegger, N ^{[1
]}

Gadner, H ^{[1
]}

Haas, OA ^{[1
]}

机构：

[1] St Anna Childrens Hosp, Childrens Canc Res Inst, A-1090 Vienna, Austria

来源：

LEUKEMIA | 2004年 / 18卷 / 10期

基金：

奥地利科学基金会;

关键词：

acute lymphoblastic leukemia; TEL/AML1; fluorescence in situ hybridization; TEL deletion;

D O I：

10.1038/sj.leu.2403471

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of the present study was to determine the frequency and clinical relevance of the most common secondary karyotype abnormalities in TEL/AML1+ B-cell precursor acute lymphoblastic leukemia ( ALL) as assessed with fluorescence in situ hybridization ( FISH) analyses. Screening of 372 patients who were enrolled in two consecutive Austrian childhood ALL multicenter trials identified 94 (25%) TEL/AML1+ cases. TEL deletions, trisomy 21 and an additional der(21) t(12; 21) were detected in 52 (55%), 13 (14%) and 14 (15%) TEL/AML1+ patients, respectively. The 12p aberrations ( P = 0.001) and near tetraploidy ( P = 0.045) were more common in TEL/AML1+ patients, whereas the incidence of diploidy, pseudodiploidy, hypodiploidy, low hyperdiploidy, near triploidy, del(6q), chromosome 9 and 11q23 abnormalities was similar among TEL/ AML1+ and TEL/AML1- patients. None of the TEL/AML1+ patients had a high hyperdiploid karyotype. Univariate analysis indicated that among TEL/ AML1+ patients those with a deletion of the nontranslocated TEL allele had a worse prognosis than those without this abnormality ( P = 0.034). We concluded that the type and incidence of the most common secondary aberrations in TEL/ AML1+ ALL can be conveniently identified with little additional effort during interphase screening with appropriate TEL and AML1 FISH probes. We also provided preliminary evidence that the deletion of the nontranslocated TEL allele may adversely influence the clinical course of TEL/ AML1+ ALL.

引用

页码：1611 / 1616

页数：6

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