Increased brain NAD prevents neuronal apoptosis in vivo

被引：58

作者：

Mukherjee, SK ^{[1
]}

Klaidman, LK ^{[1
]}

Yasharel, R ^{[1
]}

Adams, JD ^{[1
]}

机构：

[1] UNIV SO CALIF,SCH PHARM,DEPT MOL PHARMACOL & TOXICOL,PSC 508,LOS ANGELES,CA 90033

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 330卷 / 01期

关键词：

apoptosis; DNA fragmentation; MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine); nicotinamide;

D O I：

10.1016/S0014-2999(97)00171-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Apoptosis is a characteristic form of cell death which has been implicated in neurodegeneration. In this study we document the induction of apoptosis and DNA fragmentation in vivo by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a neurotoxin. MPTP selectively damages dopaminergic neurons in the substantia nigra of the midbrain. It is a potent inducer of oxygen radicals. Nicotinamide, a precursor of NAD, is able to block the apoptosis induced by MPTP. Nicotinamide also quenches some of the radicals formed by xanthine oxidase. Nicotinamide may be of interest in the treatment of neurodegeneration. (C) 1997 Elsevier Science B.V.

引用

页码：27 / 34

页数：8

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