AMPAR trafficking in synapse maturation and plasticity

被引：93

作者：

Bassani, Silvia ^{[1
]}

Folci, Alessandra ^{[1
]}

Zapata, Jonathan ^{[1
]}

Passafaro, Maria ^{[1
,2
]}

机构：

[1] Univ Milan, CNR, Inst Neurosci, Dept Med Pharmacol, Milan, Italy

[2] Dulbecco Telethon Inst, Rome, Italy

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2013年 / 70卷 / 23期

关键词：

AMPAR trafficking; Synaptic plasticity; Synapse maturation; LONG-TERM POTENTIATION; IONOTROPIC GLUTAMATE RECEPTORS; ACTIVITY-DEPENDENT REGULATION; NECROSIS-FACTOR-ALPHA; TRANSMEMBRANE AUXILIARY SUBUNITS; MAGUK SCAFFOLDING PROTEINS; DOMAIN-CONTAINING PROTEINS; KINASE-C-ALPHA; HIPPOCAMPAL-NEURONS; HOMEOSTATIC PLASTICITY;

D O I：

10.1007/s00018-013-1309-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Glutamate ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors (AMPARs) mediate most fast excitatory synaptic transmission in the central nervous system. The content and composition of AMPARs in postsynaptic membranes (which determine synaptic strength) are dependent on the regulated trafficking of AMPAR subunits in and out of the membranes. AMPAR trafficking is a key mechanism that drives nascent synapse development, and is the main determinant of both Hebbian and homeostatic plasticity in mature synapses. Hebbian plasticity seems to be the biological substrate of at least some forms of learning and memory; while homeostatic plasticity (also known as synaptic scaling) keeps neuronal circuits stable by maintaining changes within a physiological range. In this review, we examine recent findings that provide further understanding of the role of AMPAR trafficking in synapse maturation, Hebbian plasticity, and homeostatic plasticity.

引用

页码：4411 / 4430

页数：20

共 254 条

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