Nanoscaffolds in promoting regeneration of the peripheral nervous system

被引：33

作者：

Chen Aijie ^{[1
,2
]}

Lai Xuan ^{[1
]}

Liang Huimin ^{[1
]}

Zhang Yanli ^{[1
]}

Kang Yiyuan ^{[1
]}

Lin Yuqing ^{[1
]}

Shao Longquan ^{[1
,2
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, 1838 Guangzhou Ave North, Guangzhou 510515, Guangdong, Peoples R China

[2] Guangdong Prov Key Lab Construct & Detect Tissue, Guangzhou 510515, Guangdong, Peoples R China

来源：

NANOMEDICINE | 2018年 / 13卷 / 09期

基金：

中国国家自然科学基金;

关键词：

biological microenvironment; material properties; nanoscaffold; nerve guidance conduits; nerve regeneration; peripheral nerve system; NEURAL STEM-CELLS; CILIARY NEUROTROPHIC FACTOR; SCHWANN-CELL; NEURITE OUTGROWTH; NANOFIBER SCAFFOLDS; CARBON NANOTUBES; FUNCTIONAL REGENERATION; ELECTROSPUN NANOFIBERS; WALLERIAN DEGENERATION; ELECTRICAL-STIMULATION;

D O I：

10.2217/nnm-2017-0389

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

The ability to surgically repair peripheral nerve injuries is urgently needed. However, traditional tissue engineering techniques, such as autologous nerve transplantation, have some limitations. Therefore, tissue engineered autologous nerve grafts have become a suitable choice for nerve repair. Novel tissue engineering techniques derived from nanostructured conduits have been shown to be superior to other successful functional neurological structures with different scaffolds in terms of providing the required structures and properties. Additionally, different biomaterials and growth factors have been added to nerve scaffolds to produce unique biological effects that promote nerve regeneration and functional recovery. This review summarizes the application of different nanoscaffolds in peripheral nerve repair and further analyzes how the nanoscaffolds promote peripheral nerve regeneration.

引用

页码：1067 / 1085

页数：19

共 149 条

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