Efficient transformation of propargylic alcohols to α,β-unsaturated aldehydes catalyzed by ruthenium/water under neutral conditions

被引：72

作者：

Suzuki, T

Tokunaga, M

Wakatsuki, Y ^{[1
]}

机构：

[1] RIKEN, Inst Phys & Chem Res, Wako, Saitama 3510198, Japan

[2] PRESTO, Japan Sci & Technol Corp, Kawaguchi, Saitama 3320012, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 42期

关键词：

hydration; propargylic alcohol; aldehyde; ruthenium catalyst;

D O I：

10.1016/S0040-4039(02)01821-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha,beta-Unsaturated aldehydes were selectively obtained in high yields from propargylic alcohols in aqueous solutions Using RuCpCl(PR3)(2) (Cp = eta(5)-C5H5) as a catalyst. Of the tert-phosphine ligands examined, PMe3 gave the most satisfactory results. Typically, RuCpCl(PMe3)(2) (5 mol%) catalyzed the transformation of oct-1-yn-3-ol at 100degreesC to give 2-octenal in an isolated yield of 85% (E/Z-80/20). (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：7531 / 7533

页数：3

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