Conjugated Polyelectrolytes as New Platforms for Drug Screening

被引：19

作者：

An, Lingling ^{[1
]}

Wang, Shu ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2009年 / 4卷 / 08期

基金：

中国国家自然科学基金;

关键词：

conjugated polyelectrolytes; DNA recognition; fluorescent probes; drug discovery; sensitivity; TIME FLUORESCENCE ASSAY; HIGHLY SENSITIVE DETECTION; GOLD-NANOPARTICLE; INTERPOLYELECTROLYTE COMPLEXES; DIRECT VISUALIZATION; PROTEASE ACTIVITY; NUCLEIC-ACIDS; DNA DETECTION; QUANTUM DOTS; POLYMER;

D O I：

10.1002/asia.200900148

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In recent years, conjugated polyelectrolytes (CPEs) have attracted increasing attention for their applications in highly sensitive biosensors by taking advantage of their unique optical amplification properties. In comparison to previous applications tailored for highly sensitive biomacromolecule detection, this Focus Review highlights recent research efforts in the development of watersoluble CPEs as a new class of optical platforms for the screening of potential drugs. Three types of biological targets for the search of small-molecule active drugs are described: nucleic acids, enzymes, and RNA-protein complexes. Future research directions for drug screening based on CPEs are also presented.

引用

页码：1196 / 1206

页数：11

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