CD157, the Janus of CD38 but with a unique personality

被引:45
作者
Ortolan, E
Vacca, P
Capobianco, A
Armando, E
Crivellin, F
Horenstein, A
Malavasi, F
机构
[1] Univ Turin, Sch Med, Dept Genet Biol & Biochem, Immunogenet Lab, I-10126 Turin, Italy
[2] San Giovanni Battista Hosp, Expt Med Res Ctr, Turin, Italy
关键词
CD157; CD38; ectoenzyme; ADP-ribosyl cyclase; NAD(+) glycohydrolase;
D O I
10.1002/cbf.978
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
CD157 is a pleiotropic ectoenzyme which belongs to the CD38 family and to the growing number of leukocyte surface molecules known to act independently as both receptors and enzymes. A 45-kDa surface structure with a GPI anchor, the CD157 molecule displays two distinct domains in its extracellular component. The first is implicated in the enzymic activities of the molecule and the second features adhesion/signalling properties. CD157 shares several characteristics with CD38, including a similar amino acid sequence and enzymic functions. Both molecules are involved in the metabolism of NAD+, and the CD157 gene is synthenic on 4p15 with CD38, with which it also shares a unique genomic organization. Their conservation in phylogeny is striking evidence for their relevance in the life and death cycle of the cell. Copyright (C) 2002 John Wiley Sons, Ltd.
引用
收藏
页码:309 / 322
页数:14
相关论文
共 95 条
[21]  
Funaro A, 1999, J BIOL REG HOMEOS AG, V13, P54
[22]   HUMAN CD38 IS ASSOCIATED TO DISTINCT MOLECULES WHICH MEDIATE TRANSMEMBRANE SIGNALING IN DIFFERENT LINEAGES [J].
FUNARO, A ;
DEMONTE, LB ;
DIANZANI, U ;
FORNI, M ;
MALAVASI, F .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (10) :2407-2411
[23]  
Funaro A, 1998, J IMMUNOL, V160, P2238
[24]   CLONING OF A CDNA-ENCODING RAT BONE-MARROW STROMAL CELL ANTIGEN-1 (BST-1) FROM THE ISLETS OF LANGERHANS [J].
FURUYA, Y ;
TAKASAWA, S ;
YONEKURA, H ;
TANAKA, T ;
TAKAHARA, J ;
OKAMOTO, H .
GENE, 1995, 165 (02) :329-330
[25]   Phenotypic characterization of human skin mast cells by combined staining with toluidine blue and CD antibodies [J].
Ghannadan, M ;
Baghestanian, M ;
Wimazal, F ;
Eisenmenger, M ;
Latal, D ;
Kargül, G ;
Walchshofer, S ;
Sillaber, C ;
Lechner, K ;
Valent, P .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1998, 111 (04) :689-695
[26]  
GODFREY DI, 1993, J IMMUNOL, V150, P4244
[27]   CONTROL POINTS IN EARLY T-CELL DEVELOPMENT [J].
GODFREY, DI ;
ZLOTNIK, A .
IMMUNOLOGY TODAY, 1993, 14 (11) :547-553
[28]   Ecto-enzymes of lymphoid cells [J].
Goding, JW ;
Howard, MC .
IMMUNOLOGICAL REVIEWS, 1998, 161 :5-10
[29]   STRUCTURAL AND BIOSYNTHETIC FEATURES OF THE MO5 HUMAN MYELOID DIFFERENTIATION ANTIGEN [J].
GOLDSTEIN, SC ;
TODD, RF .
TISSUE ANTIGENS, 1993, 41 (04) :214-218
[30]   Cyclic ADP-ribose [J].
Guse, AH .
JOURNAL OF MOLECULAR MEDICINE-JMM, 2000, 78 (01) :26-35