Asymmetric Alkynylation of Imines by Cooperative Hydrogen Bonding and Metal Catalysis

被引：102

作者：

de Armas, Pedro ^{[1
]}

Tejedor, David ^{[1
]}

Garcia-Tellado, Fernando ^{[1
]}

机构：

[1] CSIC, Dept Quim Biol & Biotecnol, Inst Prod Nat & Agrobiol, San Cristobal la Laguna 38206, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 06期

关键词：

asymmetric catalysis; Bronsted acids; cooperative catalysis; organocatalysis; transition metals; BRONSTED ACID; ENANTIOSELECTIVE SYNTHESIS; COUNTERION STRATEGY; DIRECT-ADDITION; PROPARGYLAMINES; ACETYLIDES; ALKYNES;

D O I：

10.1002/anie.200906018

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Simple and practical: The asymmetric alkynylation of imines has been revolutionized with two nice examples of a novel model of H-bonding asymmetric metal catalysis with Brønsted acids. The catalytic model comprises two well-differenti-ated and parallel catalytic cycles: one involving metallic alkynylydes (metal catalysis) and the other one using a chiral Brønsted acid (organocatalysis; see scheme; PG = protecting group). © 2010 Wiley-VCH Verlag GmbH S. Co. KGaA,.

引用

页码：1013 / 1016

页数：4

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