Alteration of gene expression in human middle ear epithelial cells induced by influenza A virus and its implication for the pathogenesis of otitis media

被引：36

作者：

Tong, HH ^{[1
]}

Long, JP ^{[1
]}

Li, DE ^{[1
]}

DeMaria, TF ^{[1
]}

机构：

[1] Ohio State Univ, Coll Med & Publ Hlth, Dept Otolaryngol, Div Otol Res, Columbus, OH 43210 USA

来源：

MICROBIAL PATHOGENESIS | 2004年 / 37卷 / 04期

关键词：

influenza A virus; gene expression; human middle ear epithelial cells; otitis media;

D O I：

10.1016/j.micpath.2004.06.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Influenza A virus infection plays a significant role in the pathogenesis of Streptococcus pneumoniae-induced acute otitis media in children. An understanding of how influenza A virus modulates host cellular responses is critically important in efforts to explore the molecular mechanisms of this synergism. We used microarray technology to characterize the mRNA expression profile in human middle ear epithelial cells induced by influenza A virus. Alterations of mRNA expression in 142 out of approximately 12,600 genes were observed at 24 h after virus infection. Of these 142 genes with altered expression, interferon inducible genes, chemokine and cytokine genes, pro- and antiapoptotic genes, signal transduction and transcription factors, cellular immune response, cell cycle and metabolism genes were the most prominent. Our results reveal several previously unknown alterations of host gene expression induced by influenza A virus which may provide new targets for further analysis of its role in this particular host-pathogen interaction. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：193 / 204

页数：12

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