Natural killer cells in human autoimmunity

被引：84

作者：

Flodstrom-Tullberg, Malin ^{[1
]}

Bryceson, Yenan T. ^{[1
]}

Shi, Fu-Dong ^{[2
,3
]}

Hoglund, Petter ^{[4
]}

Ljunggren, Hans-Gustaf ^{[1
]}

机构：

[1] Karolinska Univ Hosp, Ctr Infect Med, Dept Med, Karolinska Inst, S-14186 Stockholm, Sweden

[2] St Josephs Hosp, Barrow Neurol Inst, Dept Neurol, Phoenix, AZ 85013 USA

[3] Maricopa Cty Gen Hosp, Phoenix, AZ 85013 USA

[4] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden

来源：

CURRENT OPINION IN IMMUNOLOGY | 2009年 / 21卷 / 06期

基金：

瑞典研究理事会;

关键词：

NK-CELLS; T-CELLS; RHEUMATOID-ARTHRITIS; INHIBITORY RECEPTORS; CUTTING EDGE; ACTIVATION; ASSOCIATION; HLA; EXPRESSION; NKG2D;

D O I：

10.1016/j.coi.2009.09.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells are innate immune cells. Although INK cells are best characterized for their ability to control tumors and infections, recent data have indicated that they also are important regulatory cells by virtue of interactions with many types of immune and nonimmune cells. Thereby, they can affect the outcome of adaptive immune responses and maintain immune homeostasis. Thus, NK cells can either exacerbate or limit immune responses, including those to autoantigens. Here, we discuss current insights into the role of NK cells in human autoimmunity.

引用

页码：634 / 640

页数：7

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