KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells

被引：159

作者：

Stine, JT

Wood, C

Hill, M

Epp, A

Raport, CJ

Schweickart, VL

Endo, Y

Sasaki, T

Simmons, G

Boshoff, C

Clapham, P

Chang, Y

Moore, P

Gray, PW

Chantry, D

机构：

[1] ICOS Corp, Bothell, WA 98021 USA

[2] Kanazawa Univ, Canc Res Inst, Kanazawa, Ishikawa 920, Japan

[3] UCL Hosp, London, England

[4] Columbia Univ Coll Phys & Surg, Dept Pathol & Epidemiol, New York, NY 10032 USA

来源：

BLOOD | 2000年 / 95卷 / 04期

关键词：

D O I：

10.1182/blood.V95.4.1151.004k37_1151_1157

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Kaposi's sarcoma-associated herpesvirus (KSHV) encodes 3 genes that are homologous to cellular chemokines, vMIP-III, the product of open reading frame K4.1, is the most distantly related to human chemokines and has yet to be characterized. We have examined the interaction of vMIP-III with chemokine receptors, its expression in KS lesions, and its in ovo angiogenic properties. We show expression of vMIP-III in KS lesions and demonstrate the stimulation of angiogenesis by this chemokine, like vMIP-I and vMIP-II, in the chick chorioallantoic membrane assay. vMIP-III does not block human immunodeficiency Virus entry through the coreceptors CCR3, CCR5, or CXCR4. However, vMIP-III is an agonist for the cellular chemokine receptor CCR4. CCR4 is expressed by THP-type T cells. Consistent with this, vMIP-III preferentially chemoattracts this cell type. Because of these biologic properties and because it is expressed in KS lesions, vMIP-III may play an important role in the pathobiology of KS.

引用

收藏

页码：1151 / 1157

页数：7

相关论文

共 44 条

[1] Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation [J].

Arvanitakis, L ;

GerasRaaka, E ;

Varma, A ;

Gershengorn, MC ;

Cesarman, E .

NATURE, 1997, 385 (6614) :347-350

[2] G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator [J].

Bais, C ;

Santomasso, B ;

Coso, O ;

Arvanitakis, L ;

Raaka, EG ;

Gutkind, JS ;

Asch, AS ;

Cesarman, E ;

Gerhengorn, MC ;

Mesri, EA .

NATURE, 1998, 391 (6662) :86-89

[3] Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s [J].

Bonecchi, R ;

Bianchi, G ;

Bordignon, PP ;

D'Ambrosio, D ;

Lang, R ;

Borsatti, A ;

Sozzani, S ;

Allavena, P ;

Gray, PA ;

Mantovani, A ;

Sinigaglia, F .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (01) :129-134

[4] Divergent effects of interleukin-4 and interferon-γ on macrophage-derived chemokine Production:: An amplification circuit of polarized T helper 2 responses [J].

Bonecchi, R ;

Sozzani, S ;

Stine, JT ;

Luini, W ;

D'Amico, G ;

Allavena, P ;

Chantry, D ;

Mantovani, A .

BLOOD, 1998, 92 (08) :2668-2671

[5] Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines [J].

Boshoff, C ;

Endo, Y ;

Collins, PD ;

Takeuchi, Y ;

Reeves, JD ;

Schweickart, VL ;

Siani, MA ;

Sasaki, T ;

Williams, TJ ;

Gray, PW ;

Moore, PS ;

Chang, Y ;

Weiss, RA .

SCIENCE, 1997, 278 (5336) :290-294

[6] KAPOSIS SARCOMA-ASSOCIATED HERPESVIRUS-LIKE DNA-SEQUENCES IN AIDS-RELATED BODY-CAVITY-BASED LYMPHOMAS [J].

CESARMAN, E ;

CHANG, Y ;

MOORE, PS ;

SAID, JW ;

KNOWLES, DM .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (18) :1186-1191

[7] IDENTIFICATION OF HERPESVIRUS-LIKE DNA-SEQUENCES IN AIDS-ASSOCIATED KAPOSIS-SARCOMA [J].

CHANG, Y ;

CESARMAN, E ;

PESSIN, MS ;

LEE, F ;

CULPEPPER, J ;

KNOWLES, DM ;

MOORE, PS .

SCIENCE, 1994, 266 (5192) :1865-1869

[8] In vivo inhibition of CC and CX3C chemokine-induced leukocyte infiltration and attenuation of glomerulonephritis in Wistar-Kyoto (WKY) rats by vMIP-II [J].

Chen, SH ;

Bacon, KB ;

Li, L ;

Garcia, GE ;

Xia, YY ;

Lo, D ;

Thompson, DA ;

Siani, MA ;

Yamamoto, T ;

Harrison, JK ;

Feng, LL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (01) :193-198

[9] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-2 INFECTION AND FUSION OF CD4-NEGATIVE HUMAN CELL-LINES - INDUCTION AND ENHANCEMENT BY SOLUBLE CD4 [J].

CLAPHAM, PR ;

MCKNIGHT, A ;

WEISS, RA .

JOURNAL OF VIROLOGY, 1992, 66 (06) :3531-3537

[10]

D'Ambrosio D, 1998, J IMMUNOL, V161, P5111

← 1 2 3 4 5 →