NMR characterization of the dynamics of biomacromolecules

被引：727

作者：

Palmer, AG ^{[1
]}

机构：

[1] Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA

来源：

CHEMICAL REVIEWS | 2004年 / 104卷 / 08期

关键词：

D O I：

10.1021/cr030413t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

For the past 15 years, the experimental and theoretical methods for analyzing molecular dynamics by NMR spin relaxation spectroscopy have undergone tremendous development. Applications of these methods have expanded to encompass investigations of conformational dynamics on multiple time scales for diverse functional states of biological macromolecules in order to characterize folding, stability, and biological activity. Continued developments are expected to further enhance understanding of the biological functions of proteins, nucleic acids, and other biological macromolecules.

引用

页码：3623 / 3640

页数：18

共 214 条

[1] On the use of the stochastic Liouville equation in nuclear magnetic resonance:: Application to R1ρ relaxation in the presence of exchange [J].

Abergel, D ;

Palmer, AG .

CONCEPTS IN MAGNETIC RESONANCE PART A, 2003, 19A (02) :134-148

[2]

Abragam A., 2002, PRINCIPLES NUCL MAGN

[3] Molecular alignment of denatured states of staphylococcal nuclease with strained polyacrylamide gels and surfactant liquid crystalline phases [J].

Ackerman, MS ;

Shortle, D .

BIOCHEMISTRY, 2002, 41 (09) :3089-3095

[4] NMR ORDER PARAMETERS AND FREE-ENERGY - AN ANALYTICAL APPROACH AND ITS APPLICATION TO COOPERATIVE CA2+ BINDING BY CALBINDIN-D(9K) [J].

AKKE, M ;

BRUSCHWEILER, R ;

PALMER, AG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (21) :9832-9833

[5]

Akke M, 1997, RNA, V3, P702

[6] EFFECTS OF ION-BINDING ON THE BACKBONE DYNAMICS OF CALBINDIN-D9K DETERMINED BY N-15 NMR RELAXATION [J].

AKKE, M ;

SKELTON, NJ ;

KORDEL, J ;

PALMER, AG ;

CHAZIN, WJ .

BIOCHEMISTRY, 1993, 32 (37) :9832-9844

[7] Concerted motions in HIV-1 TAR RNA may allow access to bound state conformations: RNA dynamics from NMR residual dipolar couplings [J].

Al-Hashimi, HM ;

Gosser, Y ;

Gorin, A ;

Hu, WD ;

Majumdar, A ;

Patel, DJ .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 315 (02) :95-102

[8] Accretion of structure in staphylococcal nuclease: An N-15 NMR relaxation study [J].

Alexandrescu, AT ;

Jahnke, W ;

Wiltscheck, R ;

Blommers, MJJ .

JOURNAL OF MOLECULAR BIOLOGY, 1996, 260 (04) :570-587

[9] ANALYSIS OF CAR-PURCELL SPIN-ECHO NMR EXPERIMENTS ON MULTIPLE-SPIN SYSTEMS .2. EFFECT OF CHEMICAL EXCHANGE [J].

ALLERHAN.A ;

THIELE, E .

JOURNAL OF CHEMICAL PHYSICS, 1966, 45 (03) :902-&

[10] Comparison of aqueous molecular dynamics with NMR relaxation and residual dipolar couplings favors internal motion in a mannose oligosaccharide [J].

Almond, A ;

Bunkenborg, J ;

Franch, T ;

Gotfredsen, CH ;

Duus, JO .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (20) :4792-4802

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