Molecular Communication from Skeletal Muscle to Bone: A Review for Muscle-Derived Myokines Regulating Bone Metabolism

被引：87

作者：

Guo, Baosheng ^{[1
]}

Zhang, Zong-Kang ^{[2
]}

Liang, Chao ^{[1
]}

Li, Jie ^{[2
]}

Liu, Jin ^{[1
]}

Lu, Aiping ^{[1
]}

Zhang, Bao-Ting ^{[2
]}

Zhang, Ge ^{[1
]}

机构：

[1] Hong Kong Baptist Univ, Inst Adv Translat Med Bone & Joint Dis, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China

来源：

CALCIFIED TISSUE INTERNATIONAL | 2017年 / 100卷 / 02期

关键词：

Skeletal muscle; Bone; Myokines; GROWTH-FACTOR; IN-VITRO; BINDING-PROTEINS; MINERAL DENSITY; KEY ROLE; INTERLEUKIN-6; MYOSTATIN; EXERCISE; FOLLISTATIN; IRISIN;

D O I：

10.1007/s00223-016-0209-4

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Besides the mechanical loading-dependent paradigm, skeletal muscle also serves as an endocrine organ capable of secreting cytokines to modulate bone metabolism. In this review, we focused on reviewing the myokines involved in communication from skeletal muscle to bone, i.e. (1) myostatin and myostatin-binding proteins including follistatin and decorin, (2) interleukins including interleukin-6 (IL-6), interleukin-7 (IL-7) and interleukin-15 (IL-15), (3) insulin-like growth factor 1 (IGF-1) and its binding proteins, (4) other myokines including PGC-1 alpha-irisin system and osteoglycin (OGN). To better understand the molecular communication from skeletal muscle to bone, we have summarized the recent advances in muscle-derived cytokines regulating bone metabolism in this review.

引用

页码：184 / 192

页数：9

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