Synthesis and characterization of naphthalimide-containing peptide nucleic acid

被引：22

作者：

Ikeda, H

Nakamura, Y

Saito, I ^{[1
]}

机构：

[1] Kyoto Univ, CREST, Japan Sci & Technol Corp, Fac Engn,Dept Synthet Chem & Biol Chem, Kyoto 6068501, Japan

[2] Tokyo Univ Sci, Fac Ind Sci & Technol, Dept Biol Sci & Technol, Noda, Chiba 2788510, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 32期

关键词：

D O I：

10.1016/S0040-4039(02)01164-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Naphthalimide-containing PNA monomer unit 6 was synthesized for the preparation of PNAs containing a naphthalimide chromophore (NPNA). PNA oligomers were purified by reversed-phase HPLC and characterized by MALDI-TOF MS and UV spectra. Thermodynamic analyses revealed that the PNA oligomer containing a naphthalimide moiety at the amino terminal stabilizes PNA-DNA hybrids. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：5525 / 5528

页数：4

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