The metalloproteinase inhibitor GI5402 inhibits endotoxin-induced soluble CD27 and CD16 release in healthy humans

被引：14

作者：

Dekkers, PEP

ten Hove, T

Lauw, FN

Koene, HR

Lumley, P

van Deventer, SJH

van der Poll, T

机构：

[1] Univ Amsterdam, Acad Med Ctr, Lab Expt Internal Med, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Netherlands Red Cross Blood Transfus Serv, Cent Lab, Expt & Clin Immunol Lab, NL-1105 AZ Amsterdam, Netherlands

[3] Glaxo Wellcome, Dept Clin Pharmacol, Greenford, Middx, England

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 05期

关键词：

D O I：

10.1128/IAI.68.5.3036-3039.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Metalloproteinases have been implicated in the cleavage of a number of cell surface immune receptors. Oral administration of the metalloproteinase inhibitor GI5402 attenuated the release of soluble CD27 and CD16 into the circulation after intravenous endotoxin injection in healthy humans.

引用

收藏

页码：3036 / 3039

页数：4

相关论文

共 19 条

[1] The tumor necrosis factor ligand and receptor families [J].

Bazzoni, F ;

Beutler, B .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (26) :1717-1725

[2]

DEHAAS M, 1995, J LAB CLIN MED, V126, P330

[3]

DEJONG R, 1991, J IMMUNOL, V146, P2488

[4] The effect of a metalloproteinase inhibitor (GI5402) on tumor necrosis factor-α (TNF-α) and TNF-α receptors during human endotoxemia [J].

Dekkers, PEP ;

Lauw, FN ;

ten Hove, T ;

Velde, AAT ;

Lumley, P ;

Becherer, D ;

van Deventer, SJH ;

van der Poll, T .

BLOOD, 1999, 94 (07) :2252-2258

[5] PROCESSING OF TUMOR-NECROSIS-FACTOR-ALPHA PRECURSOR BY METALLOPROTEINASES [J].

GEARING, AJH ;

BECKETT, P ;

CHRISTODOULOU, M ;

CHURCHILL, M ;

CLEMENTS, J ;

DAVIDSON, AH ;

DRUMMOND, AH ;

GALLOWAY, WA ;

GILBERT, R ;

GORDON, JL ;

LEBER, TM ;

MANGAN, M ;

MILLER, K ;

NAYEE, P ;

OWEN, K ;

PATEL, S ;

THOMAS, W ;

WELLS, G ;

WOOD, LM ;

WOOLLEY, K .

NATURE, 1994, 370 (6490) :555-557

[6]

HINTZEN RQ, 1991, J IMMUNOL, V147, P29

[7] Membrane protein secretases [J].

Hooper, NM ;

Karran, EH ;

Turner, AJ .

BIOCHEMICAL JOURNAL, 1997, 321 :265-279

[8] THE PI-LINKED RECEPTOR FCRIII IS RELEASED ON STIMULATION OF NEUTROPHILS [J].

HUIZINGA, TWJ ;

VANDERSCHOOT, CE ;

JOST, C ;

KLAASSEN, R ;

KLEIJER, M ;

VONDEMBORNE, AEGK ;

ROOS, D ;

TETTEROO, PAT .

NATURE, 1988, 333 (6174) :667-669

[9] SOLUBLE FC-GAMMA RECEPTOR-III IN HUMAN PLASMA ORIGINATES FROM RELEASE BY NEUTROPHILS [J].

HUIZINGA, TWJ ;

DEHAAS, M ;

KLEIJER, M ;

NUIJENS, JH ;

ROOS, D ;

BORNE, AEGKV .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (02) :416-423

[10] NA-phenotype-dependent differences in neutrophil Fc gamma RIIIb expression cause differences in plasma levels of soluble Fc gamma RIII [J].

Koene, HR ;

deHaas, M ;

Kleijer, M ;

Roos, D ;

vondemBorne, AEGK .

BRITISH JOURNAL OF HAEMATOLOGY, 1996, 93 (01) :235-241