Mitochondrial processing peptidases

被引：334

作者：

Gakh, E

Cavadini, P

Isaya, G

机构：

[1] Mayo Clin & Mayo Fdn, Dept Pediat & Adolescent Med, Rochester, MN 55905 USA

[2] Mayo Clin & Mayo Fdn, Dept Biochem & Mol Biol, Rochester, MN 55905 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2002年 / 1592卷 / 01期

关键词：

mitochondrion; protein import; processing peptidase; presequence;

D O I：

10.1016/S0167-4889(02)00265-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Three peptidases are responsible for the proteolytic processing of both nuclearly and mitochondrially encoded precursor polypeptides targeted to the various subcompartments of the mitochondria. Mitochondrial processing peptidase (MPP) cleaves the vast majority of mitochondrial proteins, while inner membrane peptidase (IMP) and mitochondrial intermediate peptidase (MIP) process specific subsets of precursor polypeptides. All three enzymes are structurally and functionally conserved across species, and their human homologues begin to be recognized as potential players in mitochondrial disease. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：63 / 77

页数：15

共 133 条

[1]

Iron-dependent self assembly of recombinant yeast frataxin: Implications for Friedreich ataxia [J].