Promotion proliferation effect of a polysaccharide from Aloe barbadensis Miller on human fibroblasts in vitro

被引：38

作者：

Yao, Hong ^{[1
]}

Chen, Yan ^{[1
]}

Li, Shaoguang ^{[1
]}

Huang, Liying ^{[1
]}

Chen, Wei ^{[1
]}

Lin, Xinhua ^{[1
]}

机构：

[1] Fujian Med Univ, Coll Pharm, Dept Pharmaceut Anal, Fuzhou 350004, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2009年 / 45卷 / 02期

关键词：

Aloe barbadensis Miller; Polysaccharide; Fibroblast; Proliferation activity; Burn; Wound healing; CHEMICAL-CHARACTERIZATION; ANTIOXIDANT ACTIVITIES; VERA; GEL; IDENTIFICATION; CHINENSIS; TISSUES; GROWTH; RATS; SKIN;

D O I：

10.1016/j.ijbiomac.2009.04.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A polysaccharide fraction was isolated from fresh Aloe barbadensis Miller leaves, which can promote the wound healing of the superficial II scald model mice. The monosaccharide composition and linkage determination were investigated by methylation and GC-MS, acetylation and GC, (13)C NMR and DEPT. The results show that its glycosyl components contain D-glucose, D-galactose, D-Xylose in a molar ratio of 5:5:1, and the API consists of a backbone of -> 2)-alpha-D-Galp-(1 -> 2)-alpha-D-Glcp-(1 ->, having a branch of alpha-D-xylofuranosyl residue that is (1 -> 3) linkage at O-3 of alpha-D-galactopyranosyl residue. It was found that the API could enhance proliferation of the human fibroblasts in vitro. The mechanisms of promotion proliferation were studied preliminarily. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：152 / 156

页数：5

共 23 条

[1]

Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats [J].