Regulation of apicomplexan actin-based motility

被引：130

作者：

Baum, Jake

Papenfuss, Anthony T.

Baum, Buzz

Speed, Terence P.

Cowman, Alan F. ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Div Infect & Immun, Parkville, Vic 3050, Australia

[2] Walter & Eliza Hall Inst Med Res, Div Bioinformat, Parkville, Vic 3050, Australia

[3] Ludwig Inst Canc Res, London W1W 7BS, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2006年 / 4卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nrmicro1465

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Apicomplexan parasites are an ancient group of protozoan parasites that includes several significant pathogens of humans and animals. To target and invade host cells they use a unique form of actin-based motility, called gliding motility. At the centre of the molecular motor that underlies this unique mode of locomotion are short, highly dynamic actin filaments. Recent molecular work, along with the availability of completed genomes for several Apicomplexa, has highlighted unique features of parasite actin and its regulation-features that might provide new ways to block motility and, consequently, prevent infection and disease.

引用

收藏

页码：621 / 628

页数：8

相关论文

共 85 条

[1] Complete genome sequence of the apicomplexan, Cryptosporidium parvum [J].

Abrahamsen, MS ;

Templeton, TJ ;

Enomoto, S ;

Abrahante, JE ;

Zhu, G ;

Lancto, CA ;

Deng, MQ ;

Liu, C ;

Widmer, G ;

Tzipori, S ;

Buck, GA ;

Xu, P ;

Bankier, AT ;

Dear, PH ;

Konfortov, BA ;

Spriggs, HF ;

Iyer, L ;

Anantharaman, V ;

Aravind, L ;

Kapur, V .

SCIENCE, 2004, 304 (5669) :441-445

[2] Identification of the moving junction complex of Toxoplasma gondii:: A collaboration between distinct secretory organelles [J].

Alexander, David L. ;

Mital, Jeffrey ;

Ward, Gary E. ;

Bradley, Peter ;

Boothroyd, John C. .

PLOS PATHOGENS, 2005, 1 (02) :137-149

[3] Cloning and characterization of actin depolymerizing factor from Toxoplasma gondii [J].

Allen, ML ;

Dobrowolski, JM ;

Muller, H ;

Sibley, LD ;

Mansour, TE .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1997, 88 (1-2) :43-52

[4] Coordinated regulation of actin filament turnover by a high-molecular-weight Srv2/CAP complex, cofilin, profilin, and Aip1 [J].

Balcer, HI ;

Goodman, AL ;

Rodal, AA ;

Smith, E ;

Kugler, J ;

Heuser, JE ;

Goode, BL .

CURRENT BIOLOGY, 2003, 13 (24) :2159-2169

[5] Proteins of the ADF/cofilin family: Essential regulators of actin dynamics [J].

Bamburg, JR .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1999, 15 :185-230

[6] THE ROLE OF THE CYTOSKELETON IN PLASMODIUM-FALCIPARUM MEROZOITE BIOLOGY - AN ELECTRON-MICROSCOPIC VIEW [J].

BANNISTER, LH ;

MITCHELL, GH .

ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1995, 89 (02) :105-111

[7] A cyclase-associated protein regulates actin and cell polarity during Drosophila oogenesis and in yeast [J].

Baum, B ;

Li, W ;

Perrimon, N .

CURRENT BIOLOGY, 2000, 10 (16) :964-973

[8] Spatial control of the actin cytoskeleton in Drosophila epithelial cells [J].

Baum, B ;

Perrimon, N .

NATURE CELL BIOLOGY, 2001, 3 (10) :883-890

[9] A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites [J].

Baum, J ;

Richard, D ;

Healer, J ;

Rug, M ;

Krnajski, Z ;

Gilberger, TW ;

Green, JL ;

Holder, AA ;

Cowman, AF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (08) :5197-5208

[10] Identification of functionally important residues of Arp2/3 complex by analysis of homology models from diverse species [J].

Beltzner, CC ;

Pollard, TD .

JOURNAL OF MOLECULAR BIOLOGY, 2004, 336 (02) :551-565

← 1 2 3 4 5 6 7 8 9 →