Regulation of apicomplexan actin-based motility

被引：130

作者：

Baum, Jake

Papenfuss, Anthony T.

Baum, Buzz

Speed, Terence P.

Cowman, Alan F. ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Div Infect & Immun, Parkville, Vic 3050, Australia

[2] Walter & Eliza Hall Inst Med Res, Div Bioinformat, Parkville, Vic 3050, Australia

[3] Ludwig Inst Canc Res, London W1W 7BS, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2006年 / 4卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nrmicro1465

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Apicomplexan parasites are an ancient group of protozoan parasites that includes several significant pathogens of humans and animals. To target and invade host cells they use a unique form of actin-based motility, called gliding motility. At the centre of the molecular motor that underlies this unique mode of locomotion are short, highly dynamic actin filaments. Recent molecular work, along with the availability of completed genomes for several Apicomplexa, has highlighted unique features of parasite actin and its regulation-features that might provide new ways to block motility and, consequently, prevent infection and disease.

引用

页码：621 / 628

页数：8

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