Rofecoxib: A specific cyclooxygenase inhibitor

被引：9

作者：

Cannon, GW

机构：

[1] Vet Adm Med Ctr, Salt Lake City, UT 84148 USA

[2] Univ Utah, Div Rheumatol, Salt Lake City, UT USA

来源：

DRUGS OF TODAY | 2000年 / 36卷 / 04期

关键词：

D O I：

10.1358/dot.2000.36.4.570204

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rofecoxib is a new specific cyclooxygenase-2 inhibitor. The efficacy of rofecoxib has been established in the treatment of osteoarthritis, rheumatoid arthritis and acute pain. Rofecoxib has been approved in the United States for the treatment of osteoarthritis and acute pain. Endoscopically proven gastrointestinal ulceration is much less with rofecoxib than standard nonsteroidal antiinflammatory drugs (NSAIDs) and the ulceration rate with rofecoxib is similar to that seen with placebo. Rofecoxib appears to provide clinical benefit equivalent to standard NSAIDs with less toxicity. (C) 2000 Prous Science. Atl rights reserved.

引用

页码：255 / 262

页数：8

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