Deciphering the genetic basis of Alzheimer's disease

被引:241
作者
Selkoe, DJ [1 ]
Podlisny, MB [1 ]
机构
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA
关键词
beta-amyloid precursor protein; amyloid beta-protein; presenilin; apolipoprotein E;
D O I
10.1146/annurev.genom.3.022502.103022
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
A remarkable rise in life expectancy during the past century has made Alzheimer's disease (AD) the most common form of progressive cognitive failure in humans. Compositional analyses of the classical brain lesions, the senile (amyloid) plaques and neurofibrillary tangles, preceded and has guided the search for genetic alterations. Four genes have been unequivocally implicated in inherited forms of AD, and mutations or polymorphisms in these genes cause excessive cerebral accumulation of the amyloid beta-protein and subsequent neuronal and glial pathology in brain regions important for memory and cognition. This understanding of the genotype-to-phenotype conversions of familial AD has led to the development of pharmacological strategies to lower amyloid beta-protein levels as a way of treating or preventing all forms of the disease.
引用
收藏
页码:67 / 99
页数:35
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