Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-α

被引：37

作者：

Bennasser, Y ^{[1
]}

Badou, A ^{[1
]}

Tkaczuk, J ^{[1
]}

Bahraoui, E ^{[1
]}

机构：

[1] Univ Toulouse 3, Lab Immunol Virol, F-31062 Toulouse, France

来源：

VIROLOGY | 2002年 / 303卷 / 01期

关键词：

HIV-Tat; human monocyte; TNF-alpha; signalization;

D O I：

10.1006/viro.2002.1676

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this study we investigated the signaling pathways triggered by Tat in human monocyte to induce TNF-alpha. In monocytes, the calcium, the PKA, and the PKC pathways are highly implicated in the expression of cytokine genes. Thus, these three major signaling pathways were investigated. Our data show that (i) PKC and calcium pathways are required for TNF-a production, whereas the PKA pathway seems to be not involved; (ii) downstream from PKC, activation of NFkappaB is essential while ERK1/2 MAP kinases, even though activated by Tat, are not directly involved in the pathway signaling leading to TNF-alpha production. (C) 2002 Elsevier Science (USA).

引用

页码：174 / 180

页数：7

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