Cobalt-catalyzed cross-coupling reactions of heterocyclic chlorides with arylmagnesium halides and of polyfunctionalized arylcopper reagents with aryl bromides, chlorides, fluorides and tosylates

被引：41

作者：

Korn, Tobias J. ^{[1
]}

Schade, Matthias A. ^{[1
]}

Cheemala, Murthy N. ^{[1
]}

Wirth, Stefan ^{[1
]}

Guevara, Simon A. ^{[1
]}

Cahiez, Gerard ^{[1
]}

Knochel, Paul ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

SYNTHESIS-STUTTGART | 2006年 / 21期

关键词：

cross-coupling; transition metals; magnesium; heterocycles; halides;

D O I：

10.1055/s-2006-950290

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A range of aromatic organocopper or organomagnesium compounds undergo smooth cross-coupling reactions with aryl bromides, chlorides, fluorides and tosylates, leading to polyfunctionalized aromatics or heterocycles in the presence of cobalt salts (5-7.5 mol%) as catalysts. Very mild reaction conditions are needed and, in the case of cross-coupling with organocopper compounds, BU4NI (1 equiv) and 4-fluorostyrene (20 mol%) are essential as promoters for successful couplings.

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收藏

页码：3547 / 3574

页数：28

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