Genetic requirements of vestigial in the regulation of Drosophila wing development

被引:31
作者
Baena-López, LA [1 ]
García-Bellido, A [1 ]
机构
[1] Univ Autonoma Madrid, Consejo Super Invest Cientificas, Ctr Biol Mol Severo Ochoa, Fac Ciencias, E-28049 Madrid, Spain
来源
DEVELOPMENT | 2003年 / 130卷 / 01期
关键词
Drosophila; vestigial; wing development; inductive assimilation; cellular identity; 'Mixed' tissues;
D O I
10.1242/dev.00187
中图分类号
Q [生物科学];
学科分类号
07 [理学]; 0710 [生物学]; 09 [农学];
摘要
The gene vestigial has been proposed to act as a master gene because of its supposed capacity to initiate and drive wing development. We show that the ectopic expression of vestigial only induces ectopic outgrowths with wing cuticular differentiation and wing blade gene expression patterns in specific developmental and genetic contexts. In the process of transformation, wingless seems to be an essential but insufficient co-factor of vestigial. vestigial ectopic expression alone or vestigial plus wingless coexpression in clones differentiate 'mixed' cuticular patterns (they contain wing blade trichomes and chaetae characteristic of the endogenous surrounding tissue) and express wing blade genes only in patches of cells within the clones. In addition, we have found that these clones, in the wing imaginal disc, may cause autonomous as well as non-autonomous cuticular transformations and wing blade gene expression patterns. These non-autonomous effects in surrounding cells result from recruitment or 'inductive assimilation' of vestigial or wingless-vestigial overexpressing cells.
引用
收藏
页码:197 / 208
页数:12
相关论文
共 58 条
[1]
Abu-Shaar M, 1998, DEVELOPMENT, V125, P3821
[2]
Development - Legs, eyes, or wings - Selectors and signals make the difference [J].
Affolter, M ;
Mann, R .
SCIENCE, 2001, 292 (5519) :1080-1081
[3]
DROSOPHILA ENHANCER-TRAP TRANSPOSANTS - GENE-EXPRESSION IN CHEMOSENSORY AND MOTOR PATHWAYS AND IDENTIFICATION OF MUTANTS AFFECTED IN SMELL AND TASTE ABILITY [J].
ANAND, A ;
FERNANDES, J ;
ARUNAN, MC ;
BHOSEKAR, S ;
CHOPRA, A ;
DEDHIA, N ;
SEQUIERA, K ;
HASAN, G ;
PALAZZOLO, MJ ;
RAGHAVAN, KV ;
RODRIGUES, V .
JOURNAL OF GENETICS, 1990, 69 (03) :151-168
[4]
Azpiazu N, 2000, DEVELOPMENT, V127, P2685
[5]
BRAND AH, 1993, DEVELOPMENT, V118, P401
[6]
Drosophila development:: Scalloped and vestigial take wing [J].
Bray, S .
CURRENT BIOLOGY, 1999, 9 (07) :R245-R247
[7]
Calleja M, 2000, DEVELOPMENT, V127, P3971
[8]
Visualization of gene expression in living adult Drosophila [J].
Calleja, M ;
Moreno, E ;
Pelaz, S ;
Morata, G .
SCIENCE, 1996, 274 (5285) :252-255
[9]
Campbell G, 1998, DEVELOPMENT, V125, P4483
[10]
THE SCALLOPED GENE ENCODES A NOVEL, EVOLUTIONARILY CONSERVED TRANSCRIPTION FACTOR REQUIRED FOR SENSORY ORGAN DIFFERENTIATION IN DROSOPHILA [J].
CAMPBELL, S ;
INAMDAR, M ;
RODRIGUES, V ;
RAGHAVAN, V ;
PALAZZOLO, M ;
CHOVNICK, A .
GENES & DEVELOPMENT, 1992, 6 (03) :367-379