NRF2 and the Hallmarks of Cancer

被引：1539

作者：

de la Vega, Montserrat Rojo ^{[1
]}

Chapman, Eli ^{[1
]}

Zhang, Donna D. ^{[1
,2
]}

机构：

[1] Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA

[2] Univ Arizona, Univ Arizona Canc Ctr, Tucson, AZ 85721 USA

来源：

CANCER CELL | 2018年 / 34卷 / 01期

关键词：

TRANSCRIPTION FACTOR NRF2; EPITHELIAL-MESENCHYMAL TRANSITION; OXIDATIVE DNA-DAMAGE; HUMAN-MELANOMA CELLS; HIGH-FAT DIET; ANTIOXIDANT RESPONSE; GENE-EXPRESSION; NF-E2-RELATED FACTOR-2; KEAP1-NRF2; PATHWAY; CROSS-TALK;

D O I：

10.1016/j.ccell.2018.03.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Though recognized originally as a target of chemopreventive compounds that help prevent cancer and other maladies, accumulating evidence has established the NRF2 pathway as a driver of cancer progression, metastasis, and resistance to therapy. Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic transcription factor. In this review, we explore the roles of NRF2 in the hallmarks of cancer, indicating both tumor suppressive and tumor-promoting effects.

引用

页码：21 / 43

页数：23

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