Genomic organization, proposed alternative splicing mechanisms, and RNA editing structure of GRIK1

被引:23
作者
Barbon, A [1 ]
Barlati, S [1 ]
机构
[1] Univ Brescia, Sch Med, Dept Biomed Sci & Biotechnol, Div Biol & Genet, I-25123 Brescia, Italy
来源
CYTOGENETICS AND CELL GENETICS | 2000年 / 88卷 / 3-4期
关键词
D O I
10.1159/000015558
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In the present study, we report the genomic reconstruction of the glutamate receptor GluR5 gene (GRIK1, alias GLUR5; 402 kb) by the use of the data available in public databases. This analysis allowed characterization of the exon-intron boundaries, identification of the gene promoter region, presentation of the putative complete sequences of two GluR5 mRNA isoforms, and definition of the structure of GluR5 pre-mRNA surrounding the Q/R editing site. Copyright (C) 2000 S. Kargar AG,Basel.
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页码:236 / 239
页数:4
相关论文
共 11 条
[1]   EXPRESSION AND NOVEL SUBUNIT ISOFORMS OF GLUTAMATE-RECEPTOR GENES GLUR5 AND GLUR6 [J].
GREGOR, P ;
OHARA, BF ;
YANG, XD ;
UHL, GR .
NEUROREPORT, 1993, 4 (12) :1343-1346
[2]  
GREGOR P, 1994, HUM GENET, V94, P565
[3]   A novel method for making nested deletions and its application for sequencing of a 300 kb region of human APP locus [J].
Hattori, M ;
Tsukahara, F ;
Furuhata, Y ;
Tanahashi, H ;
Hirose, M ;
Saito, M ;
Tsukuni, S ;
Sakaki, Y .
NUCLEIC ACIDS RESEARCH, 1997, 25 (09) :1802-1808
[4]   Q/R site editing in kainate receptor GluR5 and GluRG pre-mRNAs requires distant intronic sequences [J].
Herb, A ;
Higuchi, M ;
Sprengel, R ;
Seeburg, PH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (05) :1875-1880
[5]   Making effective use of human genomic sequence data [J].
Jang, WH ;
Chen, HC ;
Sicotte, H ;
Schuler, GD .
TRENDS IN GENETICS, 1999, 15 (07) :284-286
[6]  
KORCZAK B, 1995, RECEPTOR CHANNEL, V3, P41
[7]   RNA EDITING OF HUMAN KAINATE RECEPTOR SUBUNITS [J].
NUTT, SL ;
KAMBOJ, RK .
NEUROREPORT, 1994, 5 (18) :2625-2629
[8]  
Sahara Y, 1997, J NEUROSCI, V17, P6611
[9]  
Sander T, 1997, AM J MED GENET, V74, P416
[10]   GLUTAMATE RECEPTOR CHANNELS - NOVEL PROPERTIES AND NEW CLONES [J].
SOMMER, B ;
SEEBURG, PH .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (07) :291-296