EXPRESSION AND NOVEL SUBUNIT ISOFORMS OF GLUTAMATE-RECEPTOR GENES GLUR5 AND GLUR6

被引：59

作者：

GREGOR, P

OHARA, BF

YANG, XD

UHL, GR

机构：

[1] STANFORD UNIV,DEPT BIOL SCI,SLEEP RES CTR,STANFORD,CA 94305

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205

来源：

NEUROREPORT | 1993年 / 4卷 / 12期

关键词：

HUMAN GLUTAMATE RECEPTOR GLUR5; KAINATE RECEPTOR ISOFORMS; GENE EXPRESSION; GLUTAMATE RECEPTORS IN BRAIN DEVELOPMENT;

D O I：

10.1097/00001756-199309150-00014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MOLECULAR heterogeneity of kainate-selective glutamate receptor subunits GluR5 and GluR6 was revealed by identification of a human cDNA, GluR5-1d, and a murine cDNA, GluR6-2, that each encode subunits with novel carboxy-terminal sequences. Both GluR5-1d and GluR6-2 appear to be generated by alternative splicing at analogous sites 14 codons following the fourth putative transmembrane segment. The principal transcripts of GluR5 and GluR6 were detected by Northern analyses of several regions of mammalian brains as 4 and 6 kb bands, respectively. Potential roles for these receptors in development are indicated by detection of their mRNAs in mouse embryos of 11 days gestation. These findings add to the description of the remarkable diversity of glutamate receptor gene expression.

引用

页码：1343 / 1346

页数：4

共 24 条

[1] CLONING OF A NOVEL GLUTAMATE RECEPTOR SUBUNIT, GLUR5 - EXPRESSION IN THE NERVOUS-SYSTEM DURING DEVELOPMENT
BETTLER, B
BOULTER, J
HERMANSBORGMEYER, I
OSHEAGREENFIELD, A
DENERIS, ES
MOLL, C
BORGMEYER, U
HOLLMANN, M
HEINEMANN, S
[J]. NEURON, 1990, 5 (05) : 583 - 595
[2] CLONING OF A PUTATIVE GLUTAMATE RECEPTOR - A LOW AFFINITY KAINATE-BINDING SUBUNIT
BETTLER, B
EGEBJERG, J
SHARMA, G
PECHT, G
HERMANSBORGMEYER, I
MOLL, C
STEVENS, CF
HEINEMANN, S
[J]. NEURON, 1992, 8 (02) : 257 - 265
[3] CLONING OF A CDNA FOR A GLUTAMATE RECEPTOR SUBUNIT ACTIVATED BY KAINATE BUT NOT AMPA
EGEBJERG, J
BETTLER, B
HERMANSBORGMEYER, I
HEINEMANN, S
[J]. NATURE, 1991, 351 (6329) : 745 - 748
[4] GALLO V, 1992, J NEUROSCI, V12, P1010
[5] MOLECULAR NEUROBIOLOGY OF GLUTAMATE RECEPTORS
GASIC, GP
HOLLMANN, M
[J]. ANNUAL REVIEW OF PHYSIOLOGY, 1992, 54 : 507 - 536
[6] MOLECULAR-STRUCTURE OF THE CHICK CEREBELLAR KAINATE-BINDING SUBUNIT OF A PUTATIVE GLUTAMATE RECEPTOR
GREGOR, P
MANO, I
MAOZ, I
MCKEOWN, M
TEICHBERG, VI
[J]. NATURE, 1989, 342 (6250) : 689 - 692
[7] CHROMOSOMAL LOCALIZATION OF GLUTAMATE RECEPTOR GENES - RELATIONSHIP TO FAMILIAL AMYOTROPHIC-LATERAL-SCLEROSIS AND OTHER NEUROLOGICAL DISORDERS OF MICE AND HUMANS
GREGOR, P
REEVES, RH
JABS, EW
YANG, XD
DACKOWSKI, W
ROCHELLE, JM
BROWN, RH
HAINES, JL
OHARA, BF
UHL, GR
SELDIN, MF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (07) : 3053 - 3057
[8] ORGANIZATION AND EXPRESSION OF THE GENE ENCODING CHICK KAINATE BINDING-PROTEIN, A MEMBER OF THE GLUTAMATE RECEPTOR FAMILY
GREGOR, P
YANG, XD
MANO, I
TAKEMURA, M
TEICHBERG, VI
UHL, GR
[J]. MOLECULAR BRAIN RESEARCH, 1992, 16 (3-4): : 179 - 186
[9] THE KA-2 SUBUNIT OF EXCITATORY AMINO-ACID RECEPTORS SHOWS WIDESPREAD EXPRESSION IN BRAIN AND FORMS ION CHANNELS WITH DISTANTLY RELATED SUBUNITS
HERB, A
BURNASHEV, N
WERNER, P
SAKMANN, B
WISDEN, W
SEEBURG, PH
[J]. NEURON, 1992, 8 (04) : 775 - 785
[10] DETERMINANTS OF CA2+ PERMEABILITY IN BOTH TM1 AND TM2 OF HIGH-AFFINITY KAINATE RECEPTOR CHANNELS - DIVERSITY BY RNA EDITING
KOHLER, M
BURNASHEV, N
SAKMANN, B
SEEBURG, PH
[J]. NEURON, 1993, 10 (03) : 491 - 500

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