From functional genomics to functional immunomics: New challenges, old problems, big rewards

被引：51

作者：

Braga-Neto, Ulisses M. ^{[1
]}

Marques, Ernesto T. A., Jr.

机构：

[1] Fiocruz MS, Virol & Expt Therapy Lab, Aggeu Magalhaes Res Ctr, CPqAM, Recife, PE, Brazil

[2] Johns Hopkins Univ, Sch Med, Dept Med, Div Infect Dis, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD USA

来源：

PLOS COMPUTATIONAL BIOLOGY | 2006年 / 2卷 / 07期

关键词：

D O I：

10.1371/journal.pcbi.0020081

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of DNA microarray technology a decade ago led to the establishment of functional genomics as one of the most active and successful scientific disciplines today. With the ongoing development of immunomic microarray technology-a spatially addressable, large-scale technology for measurement of specific immunological response-the new challenge of functional immunomics is emerging, which bears similarities to but is also significantly different from functional genomics. Immunonic data has been successfully used to identify biological markers involved in autoimmune diseases, allergies, viral infections such as human immunodefficiency virus (HIV), influenza, diabetes, and responses to cancer vaccines. This review intends to provide a coherent vision of this nascent scientific field, and speculate on future research directions. We discuss at some length issues such as epitope prediction, immunomic microarray technology and its applications, and computation and statistical challenges related to functional immunomics. Based on the recent discovery of regulation mechanisms in T cell responses, we envision the use of immunomic microarrays as a tool for advances in systems biology of cellular immune responses, by means of immunomic regulatory network models.

引用

页码：651 / 662

页数：12

共 121 条

[31] Microarray profiling of antibody responses against simian-human immunodeficiency virus: Postchallenge convergence of reactivities independent of host histocompatibility type and vaccine regimen [J].

de Vegvar, HEN ;

Amara, RR ;

Steinman, L ;

Utz, PJ ;

Robinson, HL ;

Robinson, WH .

JOURNAL OF VIROLOGY, 2003, 77 (20) :11125-11138

[32] Microarrayed allergens for IgE profiling [J].

Deinhofer, K ;

Sevcik, H ;

Balic, N ;

Harwanegg, C ;

Hiller, R ;

Rumpold, H ;

Mueller, MW ;

Spitzauer, S .

METHODS, 2004, 32 (03) :249-254

[33]

Delehanty James B, 2004, Methods Mol Biol, V264, P135

[34] Transfected cell microarrays for the expression of membrane-displayed single-chain antibodies [J].

Delehanty, JB ;

Shaffer, KM ;

Lin, BC .

ANALYTICAL CHEMISTRY, 2004, 76 (24) :7323-7328

[35]

Devroye L., 1996, A probabilistic theory of pattern recognition

[36] Epistemology of computational biology: Mathematical models and experimental prediction as the basis of their validity [J].

Dougherty, ER ;

Braga-Neto, U .

JOURNAL OF BIOLOGICAL SYSTEMS, 2006, 14 (01) :65-90

[37] Preparation of steroid antibodies and parallel detection of multianabolic steroid abuse with conjugated hapten microarray [J].

Du, HW ;

Yuan, L ;

Yang, WP ;

Wu, MT ;

Jun, W ;

Shan, Z ;

Pan, MG ;

Jing, C .

ANALYTICAL CHEMISTRY, 2004, 76 (20) :6166-6171

[38]

DURBIN R, 1999, BIOL SEQUENCE ANAL

[39] A genomic view of immunology [J].

Fahrer, AM ;

Bazan, JF ;

Papathanasiou, P ;

Nelms, KA ;

Goodnow, CC .

NATURE, 2001, 409 (6822) :836-838

[40] Parallel detection of autoantibodies with microarrays in rheumatoid diseases [J].

Feng, YF ;

Ke, X ;

Ma, RS ;

Chen, P ;

Hu, GG ;

Liu, FZ .

CLINICAL CHEMISTRY, 2004, 50 (02) :416-422

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