(+)-3-[2-(benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane, as potent agonists for the α7 nicotinic acetylcholine receptor

被引：25

作者：

Tatsumi, R ^{[1
]}

Seio, K ^{[1
]}

Fujio, M ^{[1
]}

Katayama, J ^{[1
]}

Horikawa, T ^{[1
]}

Hashimoto, K ^{[1
]}

Tanaka, H ^{[1
]}

机构：

[1] Mitsubishi Pharma Corp, Pharmaceut Res Unit, Div Res & Dev, Aoba Ku, Yokohama, Kanagawa 2270023, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 14期

关键词：

alpha 7 nicotinic acetylcholine receptor;

D O I：

10.1016/j.bmcl.2004.04.091

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 3-substituted 1-azabicyclo[2.2.2]octanes was discovered as the alpha7 nicotinic acetylcholine (alpha7) receptor agonists. it was found that (+)-3-[2-(benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane (+)-15b has potent agonistic activity for the alpha7 receptor. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：3781 / 3784

页数：4

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